About: Effects of inhaled nitric oxide for postoperative hypoxemia in acute type A aortic dissection: a retrospective observational study

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About: Effects of inhaled nitric oxide for postoperative hypoxemia in acute type A aortic dissection: a retrospective observational study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Effects of inhaled nitric oxide for postoperative hypoxemia in acute type A aortic dissection: a retrospective observational study
Creator	Liu, Jian Liu, Yang Yu, Min Lu, Fanglin Zhang, Hang Han, Lin Gu, Tongtong Liu, Yaoyang Meng, Xiangdong Shi, Sheng Xu, Zhiyun Yang, Dicheng Yuan, Zhongxiang
source	PMC
abstract	BACKGROUND: Postoperative hypoxemia in acute type A aortic dissection (AADA) is a common complication and is associated with negative outcomes. This study aimed to analyze the efficacy of low-dose (5–10 ppm) inhaled nitric oxide (iNO) in the management of hypoxemia after AADA surgery. METHODS: In this retrospective observational study, Medical records of patients who underwent AADA surgery at two institutions between January 2015 and January 2018 were collected. Patients with postoperative hypoxemia were classified as iNO and control groups. Clinical characteristics and outcomes were compared using a propensity score-matched (PSM) analysis. RESULTS: Among 436 patients who underwent surgical repair, 187 (42.9%) had hypoxemia and 43 were treated with low-dose iNO. After PSM, patients were included in the iNO treatment (n = 40) and PSM control (n = 94) groups in a 1:3 ratio. iNO ameliorated hypoxemia at 6, 24, 48, and 72 h after initiation, and shortened the durations of ventilator support (39.0 h (31.3–47.8) vs. 69.0 h (47.8–110.3), p < 0.001) and ICU stay (122.0 h (80.8–155.0) vs 179.5 h (114.0–258.0), p < 0.001). There were no significant between-group differences in mortality, complications, or length of hospital stay. CONCLUSIONS: In this study, we found that low-dose iNO improved oxygenation in patients with hypoxemia after AADA surgery and shortened the durations of mechanical ventilation and ICU stay. No significant side effects or increase in postoperative mortality or morbidities were observed with iNO treatment. These findings warrant a randomized multicenter controlled trial to assess the exact efficiency of iNO for hypoxemia after AADA.
has issue date	2020-01-22(xsd:dateTime)
bibo:doi	10.1186/s13019-020-1069-6
bibo:pmid	31969173
has license	cc-by
sha1sum (hex)	8b2aa0ba21e7dc12712d0766ca7815a67fbe245a
schema:url	https://doi.org/10.1186/s13019-020-1069-6
resource representing a document's title	Effects of inhaled nitric oxide for postoperative hypoxemia in acute type A aortic dissection: a retrospective observational study
has PubMed Central identifier	PMC6977331
has PubMed identifier	31969173
schema:publication	J Cardiothorac Surg
resource representing a document's body	covid:8b2aa0ba21e7dc12712d0766ca7815a67fbe245a#body_text
is schema:about of	named entity 'classified' named entity 'control groups' named entity 'surgery' named entity 'hypoxemia' named entity 'Medical records' named entity 'negative' named entity 'POSTOPERATIVE' named entity 'SHORTENED' named entity 'STUDY' named entity 'TREATMENT' named entity 'CLINICAL CHARACTERISTICS' named entity 'TREATED WITH' named entity 'HYPOXEMIA' named entity 'BACKGROUND' named entity '258' named entity 'INO' named entity 'A COMMON' named entity 'USING' named entity 'CONTROL GROUPS' named entity 'durations' named entity 'nitric oxide' named entity 'patients' named entity 'Methods' named entity 'support' named entity '2015' named entity 'nitric oxide' named entity 'hypoxemia' named entity 'iNO' named entity 'hypoxemia' named entity 'nitric oxide' named entity 'hypoxemia' named entity 'SPSS' named entity 'thrombocytopenia' named entity 'iNO' named entity 'iNO' named entity 'fraction of inspired oxygen' named entity 'estimated glomerular filtration rate' named entity 'inflammation' named entity 'vascular endothelium' named entity 'cardiopulmonary bypass' named entity 'pulse oximeter' named entity 'hypoxemia' named entity 'Venturi mask' named entity 'acute kidney injury' named entity 'lungs' named entity 'iNO' named entity 'hypotension' named entity '1, 2' named entity 'hypoxemia' named entity 'ventilator support' named entity 'ppm' named entity 'PSM' named entity 'Mann-Whitney' named entity 'Postoperative' named entity 'iNO' named entity 'significant difference' named entity 'sivelestat' named entity 'embolism' named entity 'iNO' named entity 'PSM' named entity 'control groups' named entity 'cardiac output' named entity 'liver transplantation' named entity 'iNO' named entity 'cerebrovascular' named entity 'cardiac arrest' named entity 'methemoglobin' named entity 'hypoxemic' named entity 'inotropic'

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