About: Experimental coronavirus retinopathy (ECOR): Retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infection

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About: Experimental coronavirus retinopathy (ECOR): Retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Experimental coronavirus retinopathy (ECOR): Retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infection
Creator	Detrick, Barbara Chan, Chi-Chao Chin, Marian Hooks, John Hooper, Laura Lee, Maria
Source	Elsevier; Medline; PMC
abstract	Mouse hepatitis virus induces a biphasic disease in BALB/c mice that consists of an acute retinitis followed by progression to a chronic retinal degeneration with autoimmune reactivity. Retinal degeneration resistant CD-1 mice do not develop the late phase. What host factors contribute to the distinct responses to the virus are unknown. Herein, we show that IFN-α, IFN-β and IFN-γ act in concert as part of the innate immune response to the retinal infection. At day 2, high serum levels of IFN-γ, CXCL9 and CXCL10, were detected in BALB/c mice. Moreover, elevated levels of CXCL9 and CXCL10 gene expression were detected in retinal tissue. Although IFN-γ and the chemokines were detected in CD-1 mice, they were at significantly lower levels compared to BALB/c mice. These augmented innate responses observed correlated with the development of autoimmune reactivity and retinal degeneration and thus may contribute to the pathogenic processes.
has issue date	2008-01-01(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2007.09.032
bibo:pmid	18037505
has license	bronze-oa
sha1sum (hex)	8b33337f2df6c615e643c25646505f21a5a934e0
schema:url	https://doi.org/10.1016/j.jneuroim.2007.09.032
resource representing a document's title	Experimental coronavirus retinopathy (ECOR): Retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infection
has PubMed Central identifier	PMC2562577
has PubMed identifier	18037505
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:8b33337f2df6c615e643c25646505f21a5a934e0#body_text
is schema:about of	named entity 'CHEMOKINE' named entity 'MICE' named entity 'CXCL9' named entity 'retinal degeneration' named entity 'UNKNOWN' named entity 'COMPARED' named entity 'LATE PHASE' named entity 'DETECTED' named entity 'CHEMOKINES' named entity 'DO NOT' named entity 'MOUSE HEPATITIS VIRUS' covid:arg/8b33337f2df6c615e643c25646505f21a5a934e0 named entity 'HAVE' named entity 'CXCL9' named entity 'VIRUS' named entity 'PROCESSES' named entity 'IFN' named entity 'ELEVATED' named entity 'AUGMENTED' named entity 'LEVELS' named entity 'INNATE IMMUNE RESPONSE' named entity 'ACT' named entity 'PATHOGENIC' named entity 'TISSUE' named entity 'VIRUS INFECTION' named entity 'RETINOPATHY' named entity 'RESPONSE' named entity 'RESISTANT' named entity 'EXPERIMENTAL' named entity 'RETINAL DEGENERATION' named entity 'INTERFERON ' named entity 'EARLY' named entity 'CORONAVIRUS' named entity 'GENE EXPRESSION' named entity 'THESE' named entity 'CXCL10' named entity 'SUSCEPTIBLE' named entity 'WHAT' named entity 'BIPHASIC DISEASE' named entity 'OBSERVED' named entity 'CD-1' named entity 'PROGRESSION' named entity 'CORRELATED' named entity 'HIGH' named entity 'RETINITIS' named entity 'RESPONSES' named entity 'MICE' named entity 'BALB' named entity 'SERUM' named entity 'DAY 2' named entity 'RETINAL DEGENERATION' named entity 'HOST' named entity 'INFECTION' named entity 'ACUTE' named entity 'RETINAL' named entity 'CHRONIC' named entity 'DEVELOPMENT' named entity 'LOWER' named entity 'CXCL10' named entity 'AUGMENTED' named entity 'CONCERT' named entity 'DISTINCT' named entity 'CONTRIBUTE ' named entity 'PART OF' named entity 'AUTOIMMUNE' named entity 'RESPONSE TO' named entity 'REACTIVITY' named entity 'FOLLOWED BY' named entity 'IFN-γ' named entity 'expression' named entity 'correlated' named entity 'augmented' named entity 'autoimmune' named entity 'autoimmune' named entity 'Retinal degeneration' named entity 'mice'

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