About: Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China

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About: Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China
Creator	Chen, Zhong Li, Jing Wei, Li Liu, Lei Hu, Yu Li, Gang Liu, Yong Luo, Jie Peng, Peng Shan, Hong Liu, Wei Yang, Zhaowei Zhong, Nanshan Li, Chen Li, Yimin Li, J Wang, Jianming Li, Shiyue Hu, Li, ; Liu, Jiyang Zhang, Li, Zhang Liu, ; Peng, ; Lei, Chunliang Chen, Ruchong Guan, Weijie He, Jianxing Hu, Yahua Jiang, Mei Li, He Liang, Wenhua Sang, Ling Zhang, Nuofu Zhong, ; Jia, Nan Zheng, Jinping Chen, #ruchong Fu, Wanyi Hu, Ni Liang, Guan Nan, ; Ni, Zhengyi Peng, Yixiang Qiu, Shaoqin Wanyi, ; Xie, Jiaxing Yahua, ; Ye, Changjiang Zhaowei, ; Zheng, Zhijian Zhu, Shaoyong
Source	Elsevier; Medline; PMC
abstract	Background Crucial roles of hematologic and immunologic responses in progression of COVID-19 remains largely unclear. Objective We sought to address the dynamic changes of hematologic and immunologic biomarkers and their associations with severity and outcomes of the disease. Methods A retrospective study including 548 COVID-19 patients with clarified outcome (discharged or deceased) from a national cohort in China was performed. Cross-sectional and longitudinal variations were compared and the associations with different severity and outcomes were analyzed. Results On admission, the counts of lymphocytes, T cell subsets, eosinophils and platelets decreased markedly, especially in severe/critical and fatal patients. Increased neutrophil count and neutrophils-to-lymphocytes ratio were predominant in severe/critical cases or non-survivors. During hospitalization, eosinophils, lymphocytes and platelets were shown an increasing trend in survivors, but maintained lower levels or dropped significantly afterwards in non-survivors. Non-survivors kept high level or showed an upward trend for neutrophils, IL-6, procalcitonin, D-dimer, amyloid A protein and C-reactive protein, which were kept stable or shown downward trend in survivors. Positive correlation between CD8+ T cell and lymphocytes count was found in survivors but not in non-survivors. A multivariate Cox regression model suggested that restored levels of lymphocytes, eosinophils and platelets could serve as the predictors for the recovery, while progressive increases in neutrophils, basophils and IL-6 were associated with fatal outcome. Conclusions Hematologic and immunologic impairment showed a significantly different profile between survivors and non-survivors in COVID-19 patients with different severity. The longitudinal variations of these biomarkers could serve to predict recovery or fatal outcome.
has issue date	2020-05-11(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2020.05.003
bibo:pmid	32407836
has license	els-covid
sha1sum (hex)	8b78c1ebc0c43c7540b149814ee97aa2fb3e7d04
schema:url	https://doi.org/10.1016/j.jaci.2020.05.003
resource representing a document's title	Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China
has PubMed Central identifier	PMC7212968
has PubMed identifier	32407836
schema:publication	J Allergy Clin Immunol
resource representing a document's body	covid:8b78c1ebc0c43c7540b149814ee97aa2fb3e7d04#body_text
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