About: Identification and characterisation of T-cell epitopes for incorporation into dendritic cell-delivered Listeria vaccines

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About: Identification and characterisation of T-cell epitopes for incorporation into dendritic cell-delivered Listeria vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification and characterisation of T-cell epitopes for incorporation into dendritic cell-delivered Listeria vaccines
Creator	Petrovsky, Nikolai Alvarez-Dominguez, Carmen Calderon-Gonzalez, Ricardo Frande-Cabanes, Elisabet Pareja, Eduardo Tobes, Raquel
Source	Elsevier; Medline; PMC
abstract	Abstract Dendritic cells loaded with antigenic peptides, because of their safety and robust immune stimulation, would be ideal for induction of immunity to protect against listeriosis. However, there is no currently accepted method to predict which peptides derived from the Listeria proteome might confer protection. While elution of peptides from MHC molecules after Listeria infection yields high-affinity immune-dominant epitopes, these individual epitopes did not reliably confer Listeria protection. Instead we applied bioinformatic predictions of MHC class I and II epitopes to generate antigenic peptides that were then formulated with Advax™, a novel polysaccharide particulate adjuvant able to enhance cross-presentation prior to being screened for their ability to induce protective T-cell responses. A combination of at least four intermediate strength MHC-I binding epitopes and one weak MHC-II binding epitope when expressed in a single peptide sequence and formulated with Advax adjuvant induced a potent T-cell response and high TNF-α and IL-12 production by dendritic cells resulting in robust listeriosis protection in susceptible mice. This T-cell vaccine approach might be useful for the design of vaccines to protect against listeriosis or other intracellular infections.
has issue date	2015-09-30(xsd:dateTime)
bibo:doi	10.1016/j.jim.2015.05.009
bibo:pmid	26031451
has license	els-covid
sha1sum (hex)	8b840366cc384dbc56e835f14d86c7d2fec88ea5
schema:url	https://doi.org/10.1016/j.jim.2015.05.009
resource representing a document's title	Identification and characterisation of T-cell epitopes for incorporation into dendritic cell-delivered Listeria vaccines
has PubMed Central identifier	PMC7127673
has PubMed identifier	26031451
schema:publication	Journal of Immunological Methods
resource representing a document's body	covid:8b840366cc384dbc56e835f14d86c7d2fec88ea5#body_text
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