About: Antibody responses in spiral colon, ileum, and jejunum of bovine coronavirus-infected neonatal calves

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About: Antibody responses in spiral colon, ileum, and jejunum of bovine coronavirus-infected neonatal calves Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibody responses in spiral colon, ileum, and jejunum of bovine coronavirus-infected neonatal calves
Creator	Kapil, Sanjay Goyal, Sagar Trent, Ava
Source	Elsevier; Medline; PMC
abstract	Abstract A preliminary study was conducted to compare the regional intestinal immune responses of neonatal calves inoculated with virulent or attenuated bovine coronavirus (BCV) to determine the cause of reported vaccine failures. A group of 9 newborn, colostrum-deprived calves was used; two calves were inoculated with attenuated virus, four calves were infected with virulent virus (including one naturally infected calf), and three calves were uninfected controls. Calves inoculated with virulent virus produced higher titers of BCV antibodies in the intestines than those inoculated with the attenuated virus. The failure of the calves to respond to the attenuated virus was apparently due to the inability of the virus to replicate to high titers. Spiral colon, ileum, and jejunum were found to be immunologically distinct; the highest anti-BCV antibody responses were detected in spiral colon, the primary site of infection, and involved all four isotypes of bovine immunoglobulins. The antibody response in ileum was lower than in spiral colon. The immune responses developed slowly in jejunum and were associated primarily with the IgG subtypes.
has issue date	1994-05-31(xsd:dateTime)
bibo:doi	10.1016/0147-9571(94)90039-6
bibo:pmid	7924247
has license	els-covid
sha1sum (hex)	8b8c48e70ad9167e2f1c424001f26f974e649fea
schema:url	https://doi.org/10.1016/0147-9571%2894%2990039-6
resource representing a document's title	Antibody responses in spiral colon, ileum, and jejunum of bovine coronavirus-infected neonatal calves
has PubMed Central identifier	PMC7134166
has PubMed identifier	7924247
schema:publication	Comparative Immunology, Microbiology and Infectious Diseases
resource representing a document's body	covid:8b8c48e70ad9167e2f1c424001f26f974e649fea#body_text
is schema:about of	named entity 'high' named entity 'attenuated virus' named entity 'A group' covid:arg/8b8c48e70ad9167e2f1c424001f26f974e649fea named entity 'jejunum' named entity 'infected' named entity 'ileum' named entity 'primary' named entity 'inoculated' named entity 'site' named entity 'intestinal' named entity 'failures' named entity 'virus' named entity 'attenuated virus' named entity 'attenuated virus' named entity 'antibody' named entity 'colon' named entity 'antibody response' named entity 'immune responses' named entity 'bovine' named entity 'attenuated virus' named entity 'colon' named entity 'BOVINE CORONAVIRUS' named entity 'IgG1' named entity 'jejunum' named entity 'immunoglobulins' named entity 'FITC' named entity 'Cell Line' named entity 'SRID' named entity 'immune response' named entity 'macrophages' named entity 'colon' named entity 'IgA' named entity 'immune responses' named entity 'virus' named entity 'IgG1' named entity '2.0' named entity 'attenuated virus' named entity 'IgA' named entity 'virus' named entity 'IgG1' named entity 'immune response' named entity 'infection' named entity 'IgM' named entity 'antibody' named entity 'ileum' named entity 'dans' named entity 'virulent' named entity 'humid conditions' named entity 'vaccine' named entity 'IgM' named entity 'IgA' named entity 'Antibody' named entity 'colostrum' named entity 'viruses' named entity 'IgG' named entity 'virus' named entity 'jejunum' named entity 'ileum' named entity 'IgG2' named entity 'pH 9' named entity 'antibodies' named entity 'bovine' named entity 'IgG1' named entity 'IgG1' named entity 'ileum' named entity 'infection' named entity 'virus' named entity 'virus' named entity 'IgA' named entity 'IgG2' named entity 'virus' named entity 'virulent' named entity 'titer' named entity 'antibodies' named entity 'virus' named entity 'virulent' named entity 'virus' named entity 'colon'

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