About: Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India

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About: Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India
Creator	Bassat, Quique Guinovart, Caterina Lacerda, Marcus Del Portillo, Hernando Alonso, Pedro Aa, Márcia Alecrim, Maria Kochar, Abhishek Kochar, Dhanpat Kochar, Sanjay Melo, Gisely Mourão, Maria Nayak, Kailash Siqueira, André Belisa, M Magalhães, Siqueira,
Source	PMC
abstract	BACKGROUND: The benign character formerly attributed to Plasmodium vivax infection has been dismantled by the increasing number of reports of severe disease associated with infection with this parasite, prompting the need for more thorough and comprehensive characterization of the spectrum of resulting clinical complications. Endemic areas exhibit wide variations regarding severe disease frequency. This study, conducted simultaneously in Brazil and India, constitutes, to our knowledge, the first multisite study focused on clinical characterization of P. vivax severe disease. METHODS: Patients admitted with P. vivax mono-infection at reference centers in Manaus (Amazon - Brazil) and Bikaner (Rajasthan - India), where P. vivax predominates, were submitted to standard thorough clinical and laboratory evaluations in order to characterize clinical manifestations and identify concurrent co-morbidities. RESULTS: In total, 778 patients (88.0% above 12 years old) were hospitalized at clinical discretion with PCR-confirmed P. vivax mono-infection (316 in Manaus and 462 in Bikaner), of which 197 (25.3%) presented at least one severity criterion as defined by the World Health Organization (2010). Hyperlactatemia, respiratory distress, hypoglycemia, and disseminated intravascular coagulation were more frequent in Manaus. Noteworthy, pregnancy status was associated as a risk factor for severe disease (OR = 2.03; 95% CI = 1.2-3.4; P = 0.007). The overall case fatality rate was 0.3/1,000 cases in Manaus and 6.1/1,000 cases in Bikaner, with all deaths occurring among patients fulfilling at least one severity criterion. Within this subgroup, case fatality rates increased respectively to 7.5% in Manaus and 4.4% in Bikaner. CONCLUSION: P. vivax-associated severity is not negligible, and although lethality observed for complicated cases was similar, the overall fatality rate was about 20-fold higher in India compared to Brazil, highlighting the variability observed in different settings. Our observations highlight that pregnant women and patients with co-morbidities need special attention when infected by this parasite due to higher risk of complications. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12916-015-0302-y) contains supplementary material, which is available to authorized users.
has issue date	2015-03-20(xsd:dateTime)
bibo:doi	10.1186/s12916-015-0302-y
bibo:pmid	25889040
has license	cc-by
sha1sum (hex)	8be830e2cc153029607f9a0159472aa61a758ee3
schema:url	https://doi.org/10.1186/s12916-015-0302-y
resource representing a document's title	Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India
has PubMed Central identifier	PMC4404636
has PubMed identifier	25889040
schema:publication	BMC Med
resource representing a document's body	covid:8be830e2cc153029607f9a0159472aa61a758ee3#body_text
is schema:about of	named entity 'comprehensive' named entity 'Patients' named entity 'fatality' named entity 'Amazon' named entity 'Plasmodium' named entity 'admissions' named entity 'Plasmodium' named entity 'hospitals' named entity 'HYPERLACTATEMIA' named entity '0.3' named entity 'STUDY' named entity 'SPECTRUM' named entity 'FOLD' named entity 'BRAZIL' named entity 'PCR' named entity 'CHARACTER' named entity '2-3' covid:arg/8be830e2cc153029607f9a0159472aa61a758ee3 named entity 'benign' named entity 'patients' named entity 'Brazil' named entity 'highlight' named entity 'P. vivax' named entity 'frequency' named entity 'lethality' named entity 'Within' named entity 'Our' named entity 'Manaus' named entity 'study' named entity 'Conclusion' named entity 'respiratory distress' named entity 'disease' named entity 'frequent' named entity '95% CI' named entity '2.03' named entity 'India' named entity 'Manaus' named entity 'co-morbidities' named entity 'Brazil' named entity 'Manaus' named entity 'World Health Organization' named entity 'Brazil' named entity 'parasite' named entity 'Manaus' named entity 'clinical complications' named entity 'co-morbidities' named entity 'infection' named entity 'higher risk' named entity 'respiratory distress' named entity '6.1/1' named entity 'Brazil' named entity 'India' named entity 'disease' named entity 'cerebral malaria' named entity 'morbidity' named entity 'severe malaria' named entity 'clinical complications' named entity 'selection bias' named entity '49, 50' named entity 'leptospirosis' named entity 'P. vivax' named entity 'Manaus' named entity 'P. vivax' named entity 'comorbidities' named entity 'medical history'

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