About: Intraperitoneal Photodynamic Therapy Causes a Capillary-Leak Syndrome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Intraperitoneal Photodynamic Therapy Causes a Capillary-Leak Syndrome
Creator	Fraker, Douglas Spitz, Francis Canter, Robert Glatstein, Eli Hahn, Stephen Kesmodel, Susan Metz, James Mick, Rosemarie Raz, Dan
source	PMC
abstract	Background: In patients undergoing intraperitoneal (IP) photodynamic therapy (PDT), the combination of aggressive surgical debulking and light therapy causes an apparent systemic capillary-leak syndrome that necessitates significant intensive care unit (ICU) management after surgery. Methods: From May 1997 to May 2001, 65 patients underwent surgical debulking and PDT as part of an ongoing phase II trial for disseminated IP cancer. Perioperative data were reviewed retrospectively, and statistical analyses were performed to determine whether any identifiable factors were associated with the need for mechanical ventilation for longer than 1 day and with the occurrence of postoperative complications. Results: Forty-three women and 22 men (mean age, 49 years) were treated. Operative time averaged 9.8 hours, and mean estimated blood loss was 1450 mL. The mean crystalloid requirement for the first 48 hours after surgery was 29.3 L, and 49 patients required blood products. Twenty-four patients were intubated for longer than 24 hours, with a mean of 8.3 days for those intubated longer than 1 day. The median ICU stay was 4 days. Overall, 110 complications developed in 45 (69%) of the 65 patients. Significant complications included 6 patients with acute respiratory distress syndrome, 28 patients with infectious complications, and 4 patients with anastomotic complications. Statistical analyses revealed that surgery-related factors were significantly associated with these complication outcomes. Conclusions: Patients who undergo surgical debulking and IP PDT develop a significant capillary-leak syndrome after surgery that necessitates massive volume resuscitation, careful ICU monitoring, and, frequently, prolonged ventilatory support.
has issue date	2003-01-01(xsd:dateTime)
bibo:doi	10.1245/aso.2003.11.005
bibo:pmid	12794017
has license	no-cc
sha1sum (hex)	8c730d49504fb0bc59aab69adf4641308fa099fa
schema:url	https://doi.org/10.1245/aso.2003.11.005
resource representing a document's title	Intraperitoneal Photodynamic Therapy Causes a Capillary-Leak Syndrome
has PubMed Central identifier	PMC7101738
has PubMed identifier	12794017
schema:publication	Ann Surg Oncol
resource representing a document's body	covid:8c730d49504fb0bc59aab69adf4641308fa099fa#body_text
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