About: Extraction and characterization of the rhesus macaque T cell receptor β-chain genes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Extraction and characterization of the rhesus macaque T cell receptor β-chain genes
Creator	Price, David Douek, Daniel Davenport, Miles Greenaway, Hui Kurniawan, Monica Venturi, Vanessa
Source	Medline; PMC
abstract	Rhesus macaque models have been instrumental for the development and testing of vaccines prior to human studies and have provided fundamental insights into the determinants of immune efficacy in a variety of infectious diseases. However, the characterization of antigen-specific T cell receptor (TCR) repertoires during adaptive immune responses in these models has previously relied on human TCR gene assignments. Here, we extracted and characterized TCR β-chain (TRB) genes from the recently sequenced rhesus macaque genome that are homologous to the human TRB genes. Comparison of the rhesus macaque TRB genes with the human TRB genes revealed an average best-match similarity of 92.9%. Furthermore, we confirmed the usage of most rhesus macaque TRB genes by expressed TCRβ sequences within epitope-specific TCR repertoires. This primary description of the rhesus macaque TRB genes will provide a standardized nomenclature and enable better characterization of TCR usage in studies that utilize this species.
has issue date	2009-06-09(xsd:dateTime)
bibo:doi	10.1038/icb.2009.38
bibo:pmid	19506572
has license	no-cc
sha1sum (hex)	8c74c670f9001e13f725a59a04e19b7c07005d39
schema:url	https://doi.org/10.1038/icb.2009.38
resource representing a document's title	Extraction and characterization of the rhesus macaque T cell receptor β-chain genes
has PubMed Central identifier	PMC2756323
has PubMed identifier	19506572
schema:publication	Immunol Cell Biol
resource representing a document's body	covid:8c74c670f9001e13f725a59a04e19b7c07005d39#body_text
is schema:about of	named entity 'development' named entity 'adaptive immune responses' named entity 'T cell' named entity 'TRB' named entity 'sequences' named entity 'genes' named entity 'testing' named entity 'gene' named entity 'Here' named entity 'rhesus macaque' named entity 'TCR' named entity 'studies' named entity 'gene' named entity 'β-chain' named entity 'TCR' named entity 'vaccines' named entity 'cell receptor' named entity 'β-chain' named entity 'rhesus macaque' named entity 'gene' named entity 'exon' named entity 'rhesus macaque' named entity 'rhesus macaque' named entity 'rhesus macaque' named entity 'human reference' named entity 'gene' named entity 'MHC' named entity 'severe acute respiratory syndrome' named entity 'MHC' named entity 'epitopes' named entity 'rhesus macaque' named entity 'SIV' named entity 'gene' named entity 'rhesus macaque' named entity 'rhesus macaque' named entity 'cytolytic' named entity 'SIV' named entity 'rhesus macaque' named entity '5' end' named entity 'genome' named entity 'National Center for Biotechnology Information' named entity 'SARS' named entity 'exon' named entity 'database' named entity 'rhesus macaque' named entity 'CDR3' named entity 'rhesus macaque' named entity 'human reference' named entity 'rhesus macaque' named entity 'exon' named entity 'rhesus macaque' named entity 'genome' named entity 'gene' named entity 'allelic variant' named entity 'rhesus macaque' named entity 'molecular evolution' named entity 'gene' named entity 'Epstein-Barr virus' named entity 'rhesus macaque' named entity 'Mamu' named entity 'rhesus macaque' named entity 'rhesus macaque' named entity 'exons' named entity 'cytomegalovirus' named entity 'gene' named entity 'rhesus macaque' named entity 'Open Reading Frame' named entity '5' end' named entity 'A*01' named entity 'chromosome 3' named entity 'gene' named entity 'CD8 +' named entity 'exon' named entity 'rhesus macaque' named entity 'epitopes' named entity 'lymphocytes'

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