About: Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development

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About: Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development
Creator	Meng, X
Source	Elsevier; Medline; PMC
abstract	Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be a major problem to the pork industry worldwide. Increasing data indicate that PRRSV strains differ in virulence in infected pigs and are biologically, antigenically, and genetically heterogeneous. It is evident that the current vaccines, based on a single PRRSV strain, are not effective in protecting against infections with the genetically diverse field strains of PRRSV. The recent outbreaks of atypical or acute PRRS in vaccinated pigs have raised a serious concern about the efficacy of the current vaccines and provided the impetus for developing more effective vaccines. Special attention in this review is given to published work on antigenic, pathogenic and genetic variations of PRRSV and its potential implications for vaccine efficacy and development. Although there are ample data documenting the heterogeneous nature of PRRSV strains, information regarding how the heterogeneity is generated and what clinical impact it may have is very scarce. The observed heterogeneity will likely pose a major obstacle for effective prevention and control of PRRS. There remains an urgent need for fundamental research on this virus to understand the basic biology and the mechanism of heterogeneity and pathogenesis of PRRSV.
has issue date	2000-06-12(xsd:dateTime)
bibo:doi	10.1016/s0378-1135(00)00196-6
bibo:pmid	10831854
has license	no-cc
sha1sum (hex)	8c933d955d8adf7828db8ff08bd7106ea6fa448a
schema:url	https://doi.org/10.1016/s0378-1135%2800%2900196-6
resource representing a document's title	Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development
has PubMed Central identifier	PMC7117501
has PubMed identifier	10831854
schema:publication	Vet Microbiol
resource representing a document's body	covid:8c933d955d8adf7828db8ff08bd7106ea6fa448a#body_text
is schema:about of	named entity 'PIGS' named entity 'STRAINS' named entity 'VIRUS' named entity 'WORLDWIDE' named entity 'VIRULENCE' named entity 'EFFECTIVE' named entity 'CURRENT' named entity 'INFECTIONS' named entity 'POTENTIAL' named entity 'CURRENT' named entity 'PATHOGENESIS' named entity 'GENERATED' named entity 'OUTBREAKS' named entity 'RECENT' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'DEVELOPING' named entity 'INFORMATION' named entity 'INCREASING' named entity 'UNDERSTAND' named entity 'HETEROGENEOUS' named entity 'PROBLEM' covid:arg/8c933d955d8adf7828db8ff08bd7106ea6fa448a named entity 'CONCERN' named entity 'HETEROGENEITY' named entity 'VACCINE' named entity 'VACCINE DEVELOPMENT' named entity 'VACCINES' named entity 'INFECTED' named entity 'RESEARCH' named entity 'DATA' named entity 'WORK' named entity 'POSE' named entity 'HAVE' named entity 'ABOUT' named entity 'DIVERSE' named entity 'MAY HAVE' named entity 'ATTENTION' named entity 'DEVELOPMENT' named entity 'IMPACT' named entity 'SINGLE' named entity 'PORK' named entity 'PATHOGENIC' named entity 'PREVENTION AND CONTROL' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'VACCINE' named entity 'ITS' named entity 'CLINICAL' named entity 'A MAJOR' named entity 'MECHANISM' named entity 'ATYPICAL' named entity 'NATURE' named entity 'PUBLISHED' named entity 'STRAIN' named entity 'INDUSTRY' named entity 'OBSTACLE' named entity 'DOCUMENTING' named entity 'VACCINATED' named entity 'BASED' named entity 'REVIEW' named entity 'PROTECTING' named entity 'NEED FOR' named entity 'PROVIDED' named entity 'GIVEN' named entity 'OBSERVED' named entity 'WHAT' named entity 'BIOLOGICALLY' named entity 'PRRS' named entity 'URGENT' named entity 'FUTURE' named entity 'ACUTE' named entity 'SPECIAL' named entity 'GENETIC VARIATIONS' named entity 'LIKELY' named entity 'BASIC BIOLOGY' named entity 'HOW' named entity 'HETEROGENEITY' named entity 'RAISED' named entity 'pork' named entity 'vaccines' named entity 'pathogenesis' named entity 'Porcine reproductive and respiratory syndrome virus'

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