About: Receptor-mediated induction of human dermal fibroblast ectoaminopeptidase N by glucocorticoids

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About: Receptor-mediated induction of human dermal fibroblast ectoaminopeptidase N by glucocorticoids Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Receptor-mediated induction of human dermal fibroblast ectoaminopeptidase N by glucocorticoids
Creator	Mitić-Zlatković, M Stefanović, V Vlahović, P
Source	Medline; PMC
abstract	Aminopeptidase N was demonstrated in human dermal fibroblasts as an ectoenzyme. The enzyme has wide substrate specificity, with a K (m) of 0.63 mM and V (max) of 338 nmol min(−1) mg(−1). Addition of fetal calf serum to the culture medium increased aminopeptidase N activity up to 63% by 10% serum in a 48-h culture. Treatment of fibroblasts by dexamethasone increased ectoaminopeptidase N activity in a dose- and time-dependent manner. Maximal increase of aminopeptidase N occurred after treatment with 1 μM dexamethasone for 3 days. Actinomycin D, a blocker of RNA synthesis, and cycloheximide, an inhibitor of protein synthesis, did not alter basal aminopeptidase N activity. However, they prevented stimulation by dexamethasone. RU 38486, a glucocorticoid receptor antagonist, suppressed the dexamethasone-induced increase in aminopeptidase N activity. This study shows that human dermal fibroblasts contain ectoaminopeptidase N controlled by glucocorticoids through a receptor-mediated mechanism.
has issue date	1998-01-01(xsd:dateTime)
bibo:doi	10.1007/s000180050189
bibo:pmid	9676580
has license	no-cc
sha1sum (hex)	8cbdf2d3ee1d863176ac190e2d9ad65b26f4bd72
schema:url	https://doi.org/10.1007/s000180050189
resource representing a document's title	Receptor-mediated induction of human dermal fibroblast ectoaminopeptidase N by glucocorticoids
has PubMed Central identifier	PMC7082801
has PubMed identifier	9676580
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:8cbdf2d3ee1d863176ac190e2d9ad65b26f4bd72#body_text
is schema:about of	named entity 'demonstrated' named entity 'mechanism' named entity 'basal' named entity 'aminopeptidase N' named entity 'Actinomycin D' named entity 'glucocorticoids' named entity 'fetal calf serum' named entity 'ADDITION' named entity 'INHIBITOR' named entity 'DERMAL' named entity 'PROTEIN SYNTHESIS' named entity 'CULTURE MEDIUM' named entity 'STIMULATION' named entity 'RECEPTOR' named entity 'FIBROBLASTS' named entity 'GLUCOCORTICOID RECEPTOR ANTAGONIST' named entity 'DOSE' named entity 'MAX' named entity 'ACTINOMYCIN D' named entity 'inhibitor' named entity 'blocker' named entity 'culture medium' named entity 'man' named entity 'dermal fibroblasts' named entity 'manner' named entity 'induction' named entity 'fetal calf serum' named entity 'aminopeptidase' named entity 'fibroblasts' named entity 'dermal fibroblasts' named entity 'Aminopeptidase' named entity 'ectoenzyme' named entity 'dermal fibroblasts' named entity 'culture medium' named entity 'enzyme' named entity 'Human dermal fibroblasts' named entity 'haematopoietic cells' named entity 'hydrolysed' named entity 'dermal fibroblast' named entity 'aminopeptidase' named entity 'peptide' named entity 'aminopeptidase' named entity 'Aminopeptidase' named entity 'cAMP' named entity 'aminopeptidase' named entity 'aminopeptidase' named entity 'optical density' named entity 'aminopeptidase' named entity 'Enzyme activity' named entity 'dexamethasone' named entity '9 mM' named entity 'cycloheximide' named entity 'human dermal fibroblasts' named entity 'fibroblast' named entity 'angiotensin IV' named entity 'corticoids' named entity 'cytokines' named entity 'aminopeptidase' named entity 'acetate' named entity 'immunoregulatory' named entity 'extracellular medium' named entity 'aminopeptidase' named entity 'Fibroblasts' named entity 'sulphate' named entity 'IL-4' named entity 'immunoregulatory' named entity 'growth factors' named entity '3.5' named entity 'cycloheximide' named entity 'dermal fibroblasts' named entity 'ectoenzyme' named entity 'aminopeptidase' named entity 'amino acid' named entity 'fibroblasts' named entity 'Substrate specificity' named entity 'protein' named entity 'aminopeptidase' named entity 'cell growth' named entity 'enzyme'

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