About: Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines

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About: Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines
Creator	Baba, Kenji Fujino, Yasuhito Goto-Koshino, Yuko Mizukoshi, Fuminori Ohno, Koichi Setoguchi-Mukai, Asuka Tsujimoto, Hajime
Source	Elsevier; Medline; PMC
abstract	RNA interference (RNAi) is a process in which double-stranded RNA induces the post-transcriptional sequence-specific degradation of homologous messenger RNA. The present study was carried out to apply the RNAi technology to inhibit the replication of feline immunodeficiency virus (FIV). Four small interfering RNAs (siRNAs) homologous to the FIV gag gene were synthesized and transfected into a feline fibroblastic cell line chronically infected with FIV (CRFK/FIV). These synthetic siRNAs efficiently inhibited the replication of FIV. Next, we examined the effect of retroviral vector-mediated transfer of FIV-specific short hairpin RNA (shRNA) on the replication of FIV in a feline T-cell line chronically infected with FIV (FL4). The retroviral vector-mediated transfer of FIV-specific shRNA was shown to markedly inhibit the replication of FIV in the FL4 cells. These results provide useful information for the development of RNAi-based gene therapy strategy to control FIV infection.
has issue date	2007-03-10(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2006.10.033
bibo:pmid	17125939
has license	no-cc
sha1sum (hex)	8d0569b9fe93d0997ca38060117ffc6381122957
schema:url	https://doi.org/10.1016/j.vetmic.2006.10.033
resource representing a document's title	Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines
has PubMed Central identifier	PMC7117143
has PubMed identifier	17125939
schema:publication	Vet Microbiol
resource representing a document's body	covid:8d0569b9fe93d0997ca38060117ffc6381122957#body_text
is schema:about of	named entity 'FELINE IMMUNODEFICIENCY VIRUS' named entity 'feline immunodeficiency virus' named entity 'strategy' named entity 'siRNAs' named entity 'RNA interference' named entity 'Application' named entity 'REPLICATION' named entity 'CHRONICALLY' named entity 'TRANSFER' named entity 'SHORT HAIRPIN RNA' named entity 'DEVELOPMENT' named entity 'STUDY' named entity 'REPLICATION' named entity 'PROVIDE' named entity 'SYNTHETIC' named entity 'EFFECT' named entity 'APPLICATION' named entity 'SHRNA' named entity 'INFECTED' named entity 'RNA INTERFERENCE' named entity 'CELL LINES' named entity 'INFECTED CELL' named entity 'POST' named entity 'INHIBITED' named entity 'APPLY' named entity 'PRESENT' named entity 'DOUBLE-STRANDED RNA' named entity 'INHIBITING' named entity 'RETROVIRAL VECTOR' named entity 'MESSENGER RNA' named entity 'T-CELL LINE' named entity 'CELL LINE' named entity 'DEGRADATION' named entity 'GAG GENE' named entity 'TO CONTROL' named entity 'FELINE IMMUNODEFICIENCY VIRUS' named entity 'SEQUENCE' named entity 'CHRONICALLY' named entity 'SIRNAS' named entity 'EXAMINED' named entity 'IS A' named entity 'RNA INTERFERENCE' named entity 'SMALL INTERFERING RNAS' named entity 'BASED' named entity 'SYNTHESIZED' named entity 'INFECTION' named entity 'FL4' named entity 'CARRIED' named entity 'FIV' named entity 'GENE THERAPY' named entity 'SPECIFIC' named entity 'RNAI' named entity 'TRANSCRIPTIONAL' named entity 'TECHNOLOGY' named entity 'CELLS' named entity 'TO INHIBIT' named entity 'HOMOLOGOUS' named entity 'RESULTS' named entity 'PROCESS' named entity 'FELINE' named entity 'MARKEDLY' named entity 'STRATEGY' named entity 'THESE' named entity 'MEDIATED' named entity 'USEFUL INFORMATION' covid:arg/8d0569b9fe93d0997ca38060117ffc6381122957 named entity 'replication' named entity 'chronically' named entity 'siRNAs' named entity 'replication' named entity 'cell' named entity 'replication' named entity 'cells' named entity 'homologous' named entity 'FIV'

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