About: Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study
Creator	Feikin, Daniel Ebruke, Bernard Morpeth, Susan Murdoch, David Antonio, Martin Fu, Wei Goswami, Doli Li, Mengying Mwaba, John Mwansa, James Prosperi, Christine Sawatwong, Pongpun Shi, Qiyuan Whistler, Toni Zaman, Khalequ Sow, Samba Scott, G Madhi, Shabir Karron, Ruth Adrian, Peter Anthony, J Awori, Juliet Baggett, Henry Baillie, Vicky Brooks, W Deluca, Andrea Driscoll, Amanda Higdon, Melissa Howie, Stephen Knoll, Maria Kotloff, Karen Levine, Orin Park, Daniel Thea, Donald Hammitt, Laura O' Brien, Katherine Tapia, Milagritos Zeger, Scott
source	Medline; PMC
abstract	BACKGROUND. The etiologic inference of identifying a pathogen in the upper respiratory tract (URT) of children with pneumonia is unclear. To determine if viral load could provide evidence of causality of pneumonia, we compared viral load in the URT of children with World Health Organization–defined severe and very severe pneumonia and age-matched community controls. METHODS. In the 9 developing country sites, nasopharyngeal/oropharyngeal swabs from children with and without pneumonia were tested using quantitative real-time polymerase chain reaction for 17 viruses. The association of viral load with case status was evaluated using logistic regression. Receiver operating characteristic (ROC) curves were constructed to determine optimal discriminatory viral load cutoffs. Viral load density distributions were plotted. RESULTS. The mean viral load was higher in cases than controls for 7 viruses. However, there was substantial overlap in viral load distribution of cases and controls for all viruses. ROC curves to determine the optimal viral load cutoff produced an area under the curve of <0.80 for all viruses, suggesting poor to fair discrimination between cases and controls. Fatal and very severe pneumonia cases did not have higher viral load than less severe cases for most viruses. CONCLUSIONS. Although we found higher viral loads among pneumonia cases than controls for some viruses, the utility in using viral load of URT specimens to define viral pneumonia was equivocal. Our analysis was limited by lack of a gold standard for viral pneumonia.
has issue date	2017-06-15(xsd:dateTime)
bibo:doi	10.1093/cid/cix148
bibo:pmid	28575373
has license	cc-by
sha1sum (hex)	8d1ae8aa93426fbd79c96483ab83e0841ff8893c
schema:url	https://doi.org/10.1093/cid/cix148
resource representing a document's title	Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study
has PubMed Central identifier	PMC5447843
has PubMed identifier	28575373
schema:publication	Clin Infect Dis
resource representing a document's body	covid:8d1ae8aa93426fbd79c96483ab83e0841ff8893c#body_text
is schema:about of	named entity 'severe' named entity 'pneumonia' named entity 'World Health' named entity 'Study' covid:arg/8d1ae8aa93426fbd79c96483ab83e0841ff8893c named entity 'viral load' named entity 'controls' named entity 'etiologic' named entity 'upper respiratory tract' named entity 'severe pneumonia' named entity 'viral load' named entity 'Clinical Infectious Diseases' named entity 'Viral Load' named entity 'viruses' named entity 'RSV' named entity 'R Foundation' named entity 'viral load' named entity 'lung' named entity 'viral pneumonia' named entity 'chest radiograph' named entity 'oropharyngeal' named entity 'cough' named entity 'viral burden' named entity 'Zambia' named entity 'etiologies' named entity 'Copan' named entity 'viral load' named entity 'viruses' named entity 'virus' named entity 'viruses' named entity 'viral load' named entity 'coronavirus' named entity 'viral load' named entity 'HIV' named entity 'parainfluenza' named entity 'RSV' named entity 'HIV' named entity 'viral load' named entity 'PCR' named entity 'URT' named entity 'viruses' named entity 'WHO' named entity 'RSV' named entity 'pathogen'

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