About: Canonical and Noncanonical Autophagy as Potential Targets for COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Canonical and Noncanonical Autophagy as Potential Targets for COVID-19
Creator	Sola, Isabel Novoa, Beatriz Klionsky, Daniel Bello-Perez, Melissa Falco, Alberto
Source	Medline; PMC
abstract	The SARS-CoV-2 pandemic necessitates a review of the molecular mechanisms underlying cellular infection by coronaviruses, in order to identify potential therapeutic targets against the associated new disease (COVID-19). Previous studies on its counterparts prove a complex and concomitant interaction between coronaviruses and autophagy. The precise manipulation of this pathway allows these viruses to exploit the autophagy molecular machinery while avoiding its protective apoptotic drift and cellular innate immune responses. In turn, the maneuverability margins of such hijacking appear to be so narrow that the modulation of the autophagy, regardless of whether using inducers or inhibitors (many of which are FDA-approved for the treatment of other diseases), is usually detrimental to viral replication, including SARS-CoV-2. Recent discoveries indicate that these interactions stretch into the still poorly explored noncanonical autophagy pathway, which might play a substantial role in coronavirus replication. Still, some potential therapeutic targets within this pathway, such as RAB9 and its interacting proteins, look promising considering current knowledge. Thus, the combinatory treatment of COVID-19 with drugs affecting both canonical and noncanonical autophagy pathways may be a turning point in the fight against this and other viral infections, which may also imply beneficial prospects of long-term protection.
has issue date	2020-07-05(xsd:dateTime)
bibo:doi	10.3390/cells9071619
bibo:pmid	32635598
has license	cc-by
sha1sum (hex)	8d41f0c80a5d3007c94987f496247a96118cc7d7
schema:url	https://doi.org/10.3390/cells9071619
resource representing a document's title	Canonical and Noncanonical Autophagy as Potential Targets for COVID-19
has PubMed Central identifier	PMC7408018
has PubMed identifier	32635598
schema:publication	Cells
resource representing a document's body	covid:8d41f0c80a5d3007c94987f496247a96118cc7d7#body_text
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