About: E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles

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About: E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles
Creator	Tangy, Frédéric Vidalain, Pierre-Olivier Mateo, Mathieu Caro, Valérie Baize, Sylvain Baillet, Nicolas Journeaux, Alexandra Krieger, Sophie Carnec, Xavier Merabet, Othmann
Source	PMC
abstract	Lassa virus (LASV) and Mopeia virus (MOPV) are two closely related, rodent-born mammarenaviruses. LASV is the causative agent of Lassa fever, a deadly hemorrhagic fever endemic in West Africa, whereas MOPV is non-pathogenic in humans. The Z matrix protein of arenaviruses is essential to virus assembly and budding by recruiting host factors, a mechanism that remains partially defined. To better characterize the interactions involved, a yeast two-hybrid screen was conducted using the Z proteins from LASV and MOPV as a bait. The cellular proteins ITCH and WWP1, two members of the Nedd4 family of HECT E3 ubiquitin ligases, were found to bind the Z proteins of LASV, MOPV and other arenaviruses. The PPxY late-domain motif of the Z proteins is required for the interaction with ITCH, although the E3 ubiquitin-ligase activity of ITCH is not involved in Z ubiquitination. The silencing of ITCH was shown to affect the replication of the old-world mammarenaviruses LASV, MOPV, Lymphocytic choriomeningitis virus (LCMV) and to a lesser extent Lujo virus (LUJV). More precisely, ITCH was involved in the egress of virus-like particles and the release of infectious progeny viruses. Thus, ITCH constitutes a novel interactor of LASV and MOPV Z proteins that is involved in virus assembly and release.
has issue date	2019-12-31(xsd:dateTime)
bibo:doi	10.3390/v12010049
bibo:pmid	31906112
has license	cc-by
sha1sum (hex)	8dad44cafa563c90b07152ef2038e530b19edb31
schema:url	https://doi.org/10.3390/v12010049
resource representing a document's title	E3 Ligase ITCH Interacts with the Z Matrix Protein of Lassa and Mopeia Viruses and Is Required for the Release of Infectious Particles
has PubMed Central identifier	PMC7019300
has PubMed identifier	31906112
schema:publication	Viruses
resource representing a document's body	covid:8dad44cafa563c90b07152ef2038e530b19edb31#body_text
is schema:about of	named entity 'proteins' named entity 'ligases' named entity 'interaction' named entity 'release' covid:arg/8dad44cafa563c90b07152ef2038e530b19edb31 named entity 'release' named entity 'factors' named entity 'viruses' named entity 'Lujo virus' named entity 'Lassa virus' named entity 'progeny' named entity 'host' named entity 'motif' named entity 'mechanism' named entity 'Particles' named entity 'LASV' named entity 'rodent' named entity 'Lymphocytic choriomeningitis virus' named entity 'ubiquitin-ligase' named entity 'E3 ubiquitin ligases' named entity 'matrix protein' named entity 'WWP1' named entity 'LASV' named entity 'budding' named entity 'non-pathogenic' named entity 'clathrin-coated pits' named entity 'immunofluorescence' named entity 'vesicular' named entity 'yeast' named entity 'cell membranes' named entity 'WWP1' named entity 'cell lines' named entity 'ubiquitination' named entity 'protein' named entity 'transfected' named entity 'transfected' named entity 'RNA' named entity 'virus' named entity 'Nedd4' named entity 'virus' named entity 'cell lysates' named entity 'Polyvinylidene fluoride' named entity 'interact' named entity 'LCMV' named entity 'primary antibodies' named entity 'Invitrogen' named entity 'LASV' named entity 'viral budding' named entity 'GenBank' named entity 'protein' named entity 'Tsg101' named entity 'viral RNA' named entity 'Santa Clara, CA' named entity 'Arenavirus' named entity 'transfected' named entity 'DMEM' named entity 'Miltenyi Biotec' named entity 'RNA' named entity 'viruses' named entity 'protein' named entity 'LASV' named entity 'HeLa' named entity 'antibody' named entity 'immunoprecipitation' named entity 'infection' named entity 'viral entry' named entity 'VP40' named entity 'arenavirus' named entity 'ubiquitination' named entity 'HeLa' named entity 'autophagy' named entity 'Beckman Coulter'

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