About: IL-6 ameliorates acute lung injury in influenza virus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IL-6 ameliorates acute lung injury in influenza virus infection
Creator	Leu, Chia-Hsing Shiau, Ai-Li Wu, Chao-Liang Yang, Mei-Lin Chen, Shun-Hua Wang, Chung-Teng Yang, Shiu-Ju
Source	PMC
abstract	Interleukin 6 (IL-6) is involved in innate and adaptive immune responses to defend against pathogens. It also participates in the process of influenza infection by affecting viral clearance and immune cell responses. However, whether IL-6 impacts lung repair in influenza pathogenesis remains unclear. Here, we studied the role of IL-6 in acute influenza infection in mice. IL-6-deficient mice infected with influenza virus exhibited higher lethality, lost more body weight and had higher fibroblast accumulation and lower extracellular matrix (ECM) turnover in the lung than their wild-type counterparts. Deficiency in IL-6 enhanced proliferation, migration and survival of lung fibroblasts, as well as increased virus-induced apoptosis of lung epithelial cells. IL-6-deficient lung fibroblasts produced elevated levels of TGF-β, which may contribute to their survival. Furthermore, macrophage recruitment to the lung and phagocytic activities of macrophages during influenza infection were reduced in IL-6-deficient mice. Collectively, our results indicate that IL-6 is crucial for lung repair after influenza-induced lung injury through reducing fibroblast accumulation, promoting epithelial cell survival, increasing macrophage recruitment to the lung and enhancing phagocytosis of viruses by macrophages. This study suggests that IL-6 may be exploited for lung repair during influenza infection.
has issue date	2017-03-06(xsd:dateTime)
bibo:doi	10.1038/srep43829
bibo:pmid	28262742
has license	cc-by
sha1sum (hex)	8de30f4bd800d3e13f4cacdda51ce14e89ccd0dc
schema:url	https://doi.org/10.1038/srep43829
resource representing a document's title	IL-6 ameliorates acute lung injury in influenza virus infection
has PubMed Central identifier	PMC5338329
has PubMed identifier	28262742
schema:publication	Sci Rep
resource representing a document's body	covid:8de30f4bd800d3e13f4cacdda51ce14e89ccd0dc#body_text
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