About: Association of surfactant protein B gene polymorphisms (C/A-18, C/T1580, intron 4 and A/G9306) and haplotypes with bronchopulmonary dysplasia in chinese han population

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About: Association of surfactant protein B gene polymorphisms (C/A-18, C/T1580, intron 4 and A/G9306) and haplotypes with bronchopulmonary dysplasia in chinese han population Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association of surfactant protein B gene polymorphisms (C/A-18, C/T1580, intron 4 and A/G9306) and haplotypes with bronchopulmonary dysplasia in chinese han population
Creator	Yang, Hui Chang, Li-Wen Cai, Bao-Huan Li, Wen-Bin Liu (刘伟, Wei Mo, Lu-Xia Wang, Xi-Juan Xu, Hong-Tao Zhao, Ling-Xia
Source	PMC
abstract	This study aimed to investigate the association between surfactant protein B (SP-B) polymorphisms and bronchopulmonary dysplasia (BPD) in Chinese Han infants. We performed a casecontrol study including 86 infants with BPD and 156 matched controls. Genotyping was performed by sequence specific primer-polymerase chain reaction (PCR) and haplotypes were reconstructed by the fastPHASE software. The results showed that significant differences were detected in the genotype distribution of C/A-18 and intron 4 polymorphisms of SP-B gene between cases and controls. No significant differences were detected in the genotype distribution of C/T1580 or A/G9306 between the two groups. Haplotype analysis revealed that the frequency of A-del-C-A haplotype was higher in case group (0.12 to 0.05, P=0.003), whereas the frequency of C-inv-C-A haplotype was higher in control group (0.19 to 0.05, P=0.000). In addition, a significant difference was observed in the frequency of C-inv-T-A haplotype between the two groups. It was concluded that the polymorphisms of SP-B intron 4 and C/A-18 could be associated with BPD in Chinese Han infants, and the del allele of intron 4 and A allele of C/A-18 might be used as markers of susceptibility in the disease. Haplotype analysis indicated that the gene-gene interactions would play an important part in determining susceptibility to BPD.
has issue date	2013-06-17(xsd:dateTime)
bibo:doi	10.1007/s11596-013-1118-7
bibo:pmid	23771654
has license	no-cc
sha1sum (hex)	8e14619d4a09ad90f6efed43d8804493fa387b80
schema:url	https://doi.org/10.1007/s11596-013-1118-7
resource representing a document's title	Association of surfactant protein B gene polymorphisms (C/A-18, C/T1580, intron 4 and A/G9306) and haplotypes with bronchopulmonary dysplasia in chinese han population
has PubMed Central identifier	PMC7102067
has PubMed identifier	23771654
schema:publication	J Huazhong Univ Sci Technolog Med Sci
resource representing a document's body	covid:8e14619d4a09ad90f6efed43d8804493fa387b80#body_text
is schema:about of	named entity 'group' named entity 'Haplotypes' named entity 'USED' named entity 'SIGNIFICANT' named entity 'PERFORMED' named entity 'GENOTYPE' named entity 'PRIMER' named entity 'PERFORMED BY' named entity 'STUDY' named entity '0.05' named entity 'POLYMERASE CHAIN REACTION' named entity 'INCLUDING' named entity 'CASES' named entity 'specific' named entity 'PCR' named entity 'matched' named entity 'gene' named entity 'infants' named entity 'cases' named entity 'distribution' named entity 'Haplotype' named entity 'intron' named entity 'control group' named entity 'polymorphisms' named entity 'allele' named entity 'reconstructed' named entity 'haplotypes' named entity 'PCR' named entity 'gene interactions' named entity 'SP-B' named entity 'polymerase chain reaction' named entity 'Genotyping' named entity 'significant difference' named entity 'haplotype' named entity 'gene' named entity 'haplotype' named entity 'bronchopulmonary dysplasia' named entity 'genotype' named entity 'intron' named entity 'polymorphisms' named entity 'Bronchopulmonary Dysplasia' named entity 'allele' named entity 'haplotype' named entity 'risk factor' named entity 'genomic DNA' named entity 'allele' named entity 'China' named entity 'haplotype' named entity 'intron' named entity 'polymorphism' named entity 'intron' named entity 'SP-B' named entity 'polymorphism' named entity 'knockout mice' named entity 'homozygous' named entity 'dizygotic twins' named entity 'genotype' named entity 'wild-type' named entity 'restriction enzymes' named entity 'homozygous' named entity 'Han descent' named entity 'chronic lung disease' named entity 'Down-regulated' named entity 'nucleotides' named entity 'Haplotypes' named entity 'RDS' named entity 'polymorphic' named entity 'RNA processing' named entity 'genotype frequencies' named entity 'allele' named entity 'nucleotides' named entity 'genotyping' named entity 'gene'

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