About: Serologically diagnosed acute human bocavirus 1 infection in childhood community‐acquired pneumonia

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About: Serologically diagnosed acute human bocavirus 1 infection in childhood community‐acquired pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Serologically diagnosed acute human bocavirus 1 infection in childhood community‐acquired pneumonia
Creator	Söderlund-Venermo, Maria Vilas-Boas, Ana-Luisa Silva, Carolina Fontoura, Maria-Socorro Nascimento-Carvalho, Amanda Ruuskanen, \| Xu, \| Araújo, Vital Azevedo, Fausto Barreto, Bruna Braga, Daniel Cristiana, \| Câmara, Sérgio Fonseca, Taiane Jesus, Priscila Maia, José-Raimundo Matutino, Adriana Nascimento-Carvalho, M Neiva, Lais Nobre-Bastos, Monalisa Nogueira, Giorgio Oliveira, Ícaro Phd, Vuorinen Pirajá, Larissa Santana, Milena Sirmos, Uri Tytti, \| Vilar, Ticiana Vilas-Boas, Caroline Xavier-Souza, Gabriel
source	Medline; PMC
abstract	AIM: To assess the role of human bocavirus 1 (HBoV1) as a causative agent of non‐severe community‐acquired pneumonia (CAP) in children. METHODS: Patients aged 2‐59 months with non‐severe CAP (respiratory complaints and radiographic pulmonary infiltrate/consolidation) attending a University Hospital in Salvador, Brazil were enrolled in a prospective cohort. From 820 recruited children in a clinical trial (http://ClinicalTrials.gov NCT01200706), nasopharyngeal aspirate (NPA), and acute and convalescent serum samples were obtained from 759 (92.6%) patients. NPAs were tested for 16 respiratory viruses by PCR. Acute HBoV1 infection was confirmed by measuring specific IgM and IgG responses in paired serum samples. RESULTS: Respiratory viruses were detected in 693 (91.3%; 95%CI: 89.1‐93.2) CAP cases by PCR. HBoV1‐DNA was detected in 159 (20.9%; 95%CI: 18.2‐24.0) cases. Of these 159 PCR positive cases, acute HBoV1 infection was confirmed serologically in 38 cases (23.9%; 95%CI: 17.8‐31.0). Overall, acute HBoV1 infection was confirmed in 5.0% (38/759) of non‐severe CAP patients. HBoV1 was detected in 151 cases with at least one other virus making 31.7% of all multiple virus (n = 477) detections. Among all 759 cases, 216 had one respiratory virus detected, and sole HBoV1 was detected in only 8 (3.7%). Acute HBoV1 infection was serologically diagnosed in 34 (22.5%) HBoV1‐DNA‐positive cases with another virus, compared to 4 (50.0%) cases with sole virus detection (p = 0.09). CONCLUSION: HBoV1 was detected by PCR in one fifth of the children with non‐severe CAP and acute HBoV1 infection was serologically confirmed in one quarter of these cases.
has issue date	2017-10-13(xsd:dateTime)
bibo:doi	10.1002/ppul.23891
bibo:pmid	29028159
has license	no-cc
sha1sum (hex)	8e21defa06c535120d9971985e7e5f6dea5a95e7
schema:url	https://doi.org/10.1002/ppul.23891
resource representing a document's title	Serologically diagnosed acute human bocavirus 1 infection in childhood community‐acquired pneumonia
has PubMed Central identifier	PMC7167785
has PubMed identifier	29028159
schema:publication	Pediatr Pulmonol
resource representing a document's body	covid:8e21defa06c535120d9971985e7e5f6dea5a95e7#body_text
is schema:about of	named entity 'AIM' covid:arg/8e21defa06c535120d9971985e7e5f6dea5a95e7 named entity 'community-acquired pneumonia' named entity 'community-acquired pneumonia' named entity 'CAP' named entity 'community-acquired pneumonia' named entity 'causative' named entity 'community-acquired pneumonia' named entity 'human bocavirus' named entity 'clinical history' named entity 'serology' named entity 'nasopharyngeal' named entity 'specific serology' named entity 'Z-score' named entity 'human bocavirus' named entity 'pneumonia' named entity 'serologic' named entity 'PCR' named entity 'viruses' named entity 'asymptomatic infections' named entity 'viral replication' named entity 'interquartile range' named entity 'human bocavirus' named entity 'nasopharyngeal aspirate' named entity 'vomiting' named entity 'viral persistence' named entity 'viruses' named entity 'serology' named entity 'multiplex PCR' named entity 'Fisher's exact test' named entity 'PCR' named entity 'serologic' named entity 'Sample size' named entity 'viruses' named entity 'infection' named entity 'serum' named entity 'community-acquired pneumonia' named entity 'serology' named entity 'medical students' named entity 'severe malnutrition' named entity 'viruses' named entity 'viruses' named entity 'infection' named entity 'EIAs' named entity 'Social Sciences' named entity 'acute infection' named entity 'single center' named entity 'highly vulnerable' named entity 'tachypnea' named entity 'mucus' named entity '1.02' named entity 'viruses'

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