About: TCR Analyses: T-cell receptor CDR3 analysis: Molecular fingerprinting of the T-cell receptor repertoire

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About: TCR Analyses: T-cell receptor CDR3 analysis: Molecular fingerprinting of the T-cell receptor repertoire Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TCR Analyses: T-cell receptor CDR3 analysis: Molecular fingerprinting of the T-cell receptor repertoire
Creator	Maeurer, Markus
Source	PMC
abstract	T-cells play a crucial role in immune surveillance against transformed cells and intracellular infections; they are involved in auto-immune reactions. They recognize their targets, i.e. MHC / peptide complexes, trough the T-cell receptor. TCR usage determines the molecular interaction of the immune system with biologically relevant MHC/peptide molecules. The TCR coding genes (variable, diversity and junctional) determine the molecular composition of the TCR alpha and beta heterodimer. The random association of the VDJ genes constitutes the complementarity determining region 3 (CDR3) responsible for antigen recognition and TCR specificity. The molecular composition of a T-cell population can be objectively defined by measuring the CDR3 region. Qualitative and quantitative comparisons of the TCR composition in different anatomic compartments, or longitudinally over time, allow to asses the entire TCR repertoire. This methodology can be supplemented with functional T-cell based assays and aids to objectively describe any alteration in the T-cell pool. TCR CDR3 analysis is useful in immunomonitoring, e.g. examining patients after BMT or solid organ transplantation, patients with HAART therapy, or patients receiving molecularly defined vaccines.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1007/1-4020-3623-x_14
has license	no-cc
sha1sum (hex)	8e2b58e9bc212c57675cee148252d67b8077b212
schema:url	https://doi.org/10.1007/1-4020-3623-x_14
resource representing a document's title	TCR Analyses: T-cell receptor CDR3 analysis: Molecular fingerprinting of the T-cell receptor repertoire
has PubMed Central identifier	PMC7120667
schema:publication	Analyzing T Cell Responses
resource representing a document's body	covid:8e2b58e9bc212c57675cee148252d67b8077b212#body_text
is schema:about of	named entity 'TCR' named entity 'measuring' named entity 'organ transplantation' named entity 'based' named entity 'variable' named entity 'composition' named entity 'T-cell receptor' named entity 'T-CELL RECEPTOR' named entity 'BETA' named entity 'AUTO' named entity 'USAGE' named entity 'METHODOLOGY' named entity 'RANDOM' named entity 'TCR' named entity 'POOL' named entity 'RESPONSIBLE' named entity 'CODING' named entity 'QUANTITATIVE' named entity 'T-CELL' named entity 'TRANSFORMED' named entity 'REACTIONS' named entity 'IMMUNE SURVEILLANCE' named entity 'EXAMINING' named entity 'ANALYSIS' named entity 'IMMUNE SYSTEM' named entity 'ASSOCIATION' named entity 'TCR' named entity 'CDR3' named entity 'ANALYSIS' named entity 'MOLECULAR FINGERPRINTING' named entity 'VACCINES' named entity 'REPERTOIRE' named entity 'AND AIDS' named entity 'COMPLEMENTARITY DETERMINING REGION 3' named entity 'MOLECULAR COMPOSITION' named entity 'TIME' named entity 'TROUGH' named entity 'ANTIGEN RECOGNITION' named entity 'MOLECULAR INTERACTION' named entity 'PEPTIDE' named entity 'SOLID ORGAN TRANSPLANTATION' named entity 'TARGETS' named entity 'PLAY' named entity 'FUNCTIONAL' named entity 'T-CELLS' named entity 'INTRACELLULAR' named entity 'ROLE' named entity 'COMPARTMENTS' named entity 'CDR3' named entity 'COMPOSITION' named entity 'DIVERSITY' named entity 'DIFFERENT' named entity 'T-CELL RECEPTOR' named entity 'BIOLOGICALLY' named entity 'SPECIFICITY' named entity 'MEASURING' named entity 'DETERMINE' named entity 'THEIR' named entity 'DESCRIBE' named entity 'A T' named entity 'RELEVANT' named entity 'CELL POPULATION' named entity 'REGION' named entity 'IMMUNE' named entity 'INVOLVED' named entity 'ALLOW' named entity 'TCR ALPHA' named entity 'RECEIVING' named entity 'ENTIRE' named entity 'USEFUL' named entity 'INFECTIONS' named entity 'ALTERATION' named entity 'COMPLEXES' named entity 'BMT' named entity 'MHC' named entity 'DEFINED' named entity 'BASED' named entity 'GENES' named entity 'ANATOMIC' named entity 'MOLECULES' named entity 'ASSES' named entity 'QUALITATIVE' named entity 'THERAPY'

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