About: Exportin 1 inhibition as antiviral therapy

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Exportin 1 inhibition as antiviral therapy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exportin 1 inhibition as antiviral therapy
Creator	Uddin, Md Azmi, Asfar Zonder, Jeffrey Hafiz Uddin, Md
Source	Elsevier; Medline; PMC
abstract	Coronavirus 2019 (COVID-19; caused by Severe Acute Respiratory Syndrome Coronavirus 2; SARS-CoV-2) is a currently global health problem. Previous studies showed that blocking nucleocytoplasmic transport with exportin 1 (XPO1) inhibitors originally developed as anticancer drugs can quarantine key viral accessory proteins and genomic materials in the nucleus of host cell and reduce virus replication and immunopathogenicity. These observations support the concept of the inhibition of nuclear export as an effective strategy against an array of viruses, including influenza A, B, and SARS-CoV. Clinical studies using the XPO1 inhibitor selinexor as a therapy for COVID-19 infection are in progress.
has issue date	2020-06-20(xsd:dateTime)
bibo:doi	10.1016/j.drudis.2020.06.014
bibo:pmid	32569833
has license	no-cc
sha1sum (hex)	8e49b22c9df21f8f16b36b8dd50cf17d55f462de
schema:url	https://doi.org/10.1016/j.drudis.2020.06.014
resource representing a document's title	Exportin 1 inhibition as antiviral therapy
has PubMed Central identifier	PMC7305737
has PubMed identifier	32569833
schema:publication	Drug Discov Today
resource representing a document's body	covid:8e49b22c9df21f8f16b36b8dd50cf17d55f462de#body_text
is schema:about of	named entity 'EXPORT' named entity 'SIGNALING' covid:arg/8e49b22c9df21f8f16b36b8dd50cf17d55f462de named entity 'SINE' named entity 'cytoplasmic' named entity 'Exportin 1' named entity 'antiviral therapy' named entity 'IκB' named entity 'virus' named entity 'transcription factor' named entity 'proinflammatory cytokines' named entity 'IP-10' named entity 'adaptor protein' named entity 'NES' named entity 'pathology' named entity 'anticancer agents' named entity 'sepsis' named entity 'GDP' named entity 'viral infections' named entity 'Oct3/4' named entity 'preclinical' named entity 'protein' named entity 'ribonucleoproteins' named entity 'Ebola' named entity 'SARS-CoV-2' named entity 'clinical studies' named entity 'pathology' named entity 'genome editing' named entity 'selinexor' named entity 'RSV' named entity 'XPO1' named entity 'IL-18' named entity 'genetic material' named entity 'virus' named entity 'cytokine' named entity 'randomized studies' named entity 'interactome' named entity 'SINE' named entity 'SARS-CoV' named entity 'family of viruses' named entity 'viral infections' named entity 'nuclear localization signal' named entity 'Influenza' named entity 'molecular events' named entity 'amino acid' named entity 'virus' named entity 'IL-6' named entity 'leptomycin' named entity 'inflammatory processes' named entity 'viral proteins' named entity '1.1' named entity 'karyopherin' named entity 'XPO1' named entity 'macrophage inflammatory protein' named entity 'IL-2' named entity 'XPO1' named entity 'nuclear transport' named entity 'protein' named entity 'SMAD4' named entity 'viral replication' named entity 'nuclear export' named entity 'MCP-1' named entity 'cytoplasm' named entity 'RdRp' named entity 'nucleocapsid' named entity 'RNAs' named entity 'placebo' named entity 'antiviral agents' named entity 'cell biology' named entity 'NLS' named entity 'XPO1' named entity 'phosphoprotein' named entity 'CREB1' named entity 'selinexor' named entity 'avian influenza' named entity 'sepsis' named entity 'GEF' named entity 'transcription factors'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software