About: Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for Severe Acute Respiratory Syndrome coronavirus (SARS-CoV)

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About: Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for Severe Acute Respiratory Syndrome coronavirus (SARS-CoV)
Creator	Subbarao, Kanta Vogel, Leatrice Roberts, Anjeanette Zaki, Sherif Lamirande, Elaine Paddock, Christopher Genrich, Gillian Kapadia, Sagar Rose, John
Source	Elsevier; Medline; PMC
abstract	The causative agent of Severe Acute Respiratory Syndrome (SARS) was identified as a coronavirus (CoV) following the outbreak of 2002–2003. There are currently no licensed vaccines or treatments for SARS-CoV infections. Potential prevention and control strategies that show promise in vitro must be evaluated in animal models. The aged BALB/c mouse model for SARS supports a high level of viral replication in association with clinical illness and disease that mimics SARS in the elderly. We tested two preventive strategies, vaccination and passive transfer of serum antibody, to determine the extent of protection achieved against SARS-CoV challenge in this model. These approaches were able to achieve or induce antibody titers sufficient to reduce viral load, protect from weight loss, and reduce or eliminate histopathologic changes in the lungs of aged mice. This study validates the utility of the aged BALB/c mouse model for evaluation of the efficacy of vaccines and immunoprophylaxis.
has issue date	2007-03-01(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2006.11.055
bibo:pmid	17227689
has license	bronze-oa
sha1sum (hex)	8e706c240839154f4fb123d28c5b57e078703bc6
schema:url	https://doi.org/10.1016/j.vaccine.2006.11.055
resource representing a document's title	Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for Severe Acute Respiratory Syndrome coronavirus (SARS-CoV)
has PubMed Central identifier	PMC1847333
has PubMed identifier	17227689
schema:publication	Vaccine
resource representing a document's body	covid:8e706c240839154f4fb123d28c5b57e078703bc6#body_text
is schema:about of	named entity 'evaluated' named entity 'These' named entity 'prevention' named entity 'IDENTIFIED' named entity 'CURRENTLY' named entity 'SERUM' named entity 'THESE' named entity 'PROTECTION' named entity 'MICE' named entity 'CLINICAL' named entity 'VIRAL REPLICATION' named entity 'TO REDUCE' named entity 'DISEASE' named entity 'CAUSATIVE AGENT' named entity 'STUDY' named entity 'STRATEGIES' named entity 'ANTIBODY TITERS' named entity 'MODEL' named entity 'ELDERLY' named entity 'SARS-COV' covid:arg/8e706c240839154f4fb123d28c5b57e078703bc6 named entity 'MOUSE MODEL' named entity 'UTILITY' named entity 'POTENTIAL' named entity 'EFFICACY' named entity 'EVALUATED' named entity 'SARS' named entity 'PREVENTION AND CONTROL' named entity 'AGED' named entity 'STRATEGIES' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'BALB' named entity 'PREVENTION AND CONTROL' named entity 'LICENSED' named entity 'PASSIVE' named entity 'IN VITRO' named entity 'FOLLOWING' named entity 'AGED' named entity 'ILLNESS' named entity 'ANTIBODY' named entity 'IMMUNOPROPHYLAXIS' named entity 'INFECTIONS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'OUTBREAK' named entity 'CHANGES' named entity 'TESTED' named entity 'VACCINES' named entity 'UTILITY' named entity 'VACCINATION' named entity 'WEIGHT LOSS' named entity 'EVALUATION' named entity 'SUFFICIENT' named entity 'PUBLISHED' named entity 'MIMICS' named entity 'CHALLENGE' named entity 'CORONAVIRUS' named entity 'THE LUNGS' named entity 'ASSOCIATION' named entity 'DETERMINE' named entity 'TRANSFER' named entity 'HISTOPATHOLOGIC' named entity 'PROMISE' named entity 'HIGH LEVEL' named entity 'MOUSE MODEL' named entity 'BALB' named entity 'ANIMAL MODELS' named entity 'INDUCE' named entity 'REDUCE' named entity 'EXTENT OF' named entity 'APPROACHES' named entity 'VIRAL LOAD' named entity 'PREVENTIVE STRATEGIES' named entity 'TREATMENTS'

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