About: Characterizing the Transmission Potential of Zoonotic Infections from Minor Outbreaks

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterizing the Transmission Potential of Zoonotic Infections from Minor Outbreaks
Creator	Edmunds, W Open Access Citation: Kucharski, A
Source	Medline; PMC
abstract	The transmission potential of a novel infection depends on both the inherent transmissibility of a pathogen, and the level of susceptibility in the host population. However, distinguishing between these pathogen- and population-specific properties typically requires detailed serological studies, which are rarely available in the early stages of an outbreak. Using a simple transmission model that incorporates age-stratified social mixing patterns, we present a novel method for characterizing the transmission potential of subcritical infections, which have effective reproduction number R<1, from readily available data on the size of outbreaks. We show that the model can identify the extent to which outbreaks are driven by inherent pathogen transmissibility and pre-existing population immunity, and can generate unbiased estimates of the effective reproduction number. Applying the method to real-life infections, we obtained accurate estimates for the degree of age-specific immunity against monkeypox, influenza A(H5N1) and A(H7N9), and refined existing estimates of the reproduction number. Our results also suggest minimal pre-existing immunity to MERS-CoV in humans. The approach we describe can therefore provide crucial information about novel infections before serological surveys and other detailed analyses are available. The methods would also be applicable to data stratified by factors such as profession or location, which would make it possible to measure the transmission potential of emerging infections in a wide range of settings.
has issue date	2015-04-10(xsd:dateTime)
bibo:doi	10.1371/journal.pcbi.1004154
bibo:pmid	25860289
has license	cc-by
sha1sum (hex)	8e8e5b1a4c76cea327ba95e100445f08ffebf9be
schema:url	https://doi.org/10.1371/journal.pcbi.1004154
resource representing a document's title	Characterizing the Transmission Potential of Zoonotic Infections from Minor Outbreaks
has PubMed Central identifier	PMC4393285
has PubMed identifier	25860289
schema:publication	PLoS Comput Biol
resource representing a document's body	covid:8e8e5b1a4c76cea327ba95e100445f08ffebf9be#body_text
is schema:about of	named entity 'outbreaks' named entity 'analyses' named entity 'generate' named entity 'identify' named entity 'transmissibility' named entity 'POTENTIAL' named entity 'USING' named entity 'AVAILABLE' named entity 'MINIMAL' named entity 'MAKE' named entity 'IMMUNITY' named entity 'DATA' named entity 'ACCURATE' named entity 'STUDIES' named entity 'SEROLOGICAL' named entity 'SUSCEPTIBILITY' named entity 'PROPERTIES' named entity 'SOCIAL' named entity 'METHODS' named entity 'INFECTION' named entity 'SPECIFIC' named entity 'MONKEYPOX' named entity 'DEGREE' named entity 'STRATIFIED' named entity 'MODEL' named entity 'SIZE' named entity 'PATHOGEN' named entity 'SURVEYS' named entity 'PATTERNS' named entity 'OUTBREAK' named entity 'DISTINGUISHING' named entity 'THESE' named entity 'INFLUENZA A' named entity 'APPLYING' named entity 'AGE' named entity 'OBTAINED' named entity 'EARLY STAGES' named entity 'DETAILED' named entity 'NOVEL' named entity 'PROVIDE' named entity 'TO MEASURE' named entity 'HOST POPULATION' named entity 'ESTIMATES' named entity 'POSSIBLE' named entity 'PRE-EXISTING' named entity 'HUMANS' named entity 'POTENTIAL' named entity 'SIMPLE' named entity 'IDENTIFY' named entity 'GENERATE' named entity 'SETTINGS' named entity 'TRANSMISSION' named entity 'SUGGEST' named entity 'MERS-COV' named entity 'TRANSMISSION' named entity 'MINOR' named entity 'ZOONOTIC INFECTIONS' named entity 'LEVEL' named entity 'SPECIFIC IMMUNITY' named entity 'HAVE' named entity 'DESCRIBE' named entity 'METHOD' named entity 'RARELY' named entity 'POPULATION' named entity 'INFORMATION' named entity 'LOCATION' named entity 'ABOUT' named entity 'WIDE' named entity 'OUTBREAKS' named entity 'PROFESSION' named entity 'APPROACH' named entity 'OUR' named entity 'APPLICABLE' named entity 'LIFE' named entity 'REAL' named entity 'DRIVEN' named entity 'INFECTIONS' named entity 'RESULTS' named entity 'PRESENT' named entity 'MIXING'

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