About: Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children

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About: Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children
Creator	Chang, Wei-Chiao Hsu, Yu-Wen Huang, Ying-Hsien Kuo, Ho-Chang Liang, Chi-Di Yu, Hong-Ren Chang, Wei-Pin Chen, Wei-Chiao Tsai, Yao-Ting Yang, Ya-Ling Yang, Kuender
source	PMC
abstract	Background. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD. Methods. A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) of CLEC5A (rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test. Results. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and patients. In the patients, polymorphisms of CLEC5A showed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response. Conclusions. This study showed for the first time that polymorphisms of CLEC5A are not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population.
has issue date	2011-12-22(xsd:dateTime)
bibo:doi	10.1155/2012/398628
bibo:pmid	22536019
has license	no-cc
sha1sum (hex)	8ef3d0709843acf3358abcb4144c23478e817097
schema:url	https://doi.org/10.1155/2012/398628
resource representing a document's title	Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children
has PubMed Central identifier	PMC3318896
has PubMed identifier	22536019
schema:publication	J Biomed Biotechnol
resource representing a document's body	covid:8ef3d0709843acf3358abcb4144c23478e817097#body_text
is schema:about of	named entity 'disease' named entity 'intravenous immunoglobulin' named entity 'patients' named entity 'coronary artery' named entity 'Results' named entity 'ENROLLED' named entity 'USING' named entity 'HOST' named entity 'TAQMAN' named entity 'SINGLE-NUCLEOTIDE POLYMORPHISMS' named entity 'BACKGROUND' named entity 'LESIONS' named entity 'POPULATION' covid:arg/8ef3d0709843acf3358abcb4144c23478e817097 named entity 'CLEC5A' named entity 'FAMILY' named entity 'INTRAVENOUS IMMUNOGLOBULIN' named entity 'CASES' named entity 'SUSCEPTIBILITY' named entity 'DISCRIMINATION' named entity 'TAIWANESE' named entity 'CORONARY ARTERY LESION' named entity 'CORONARY ARTERY' named entity 'CONCLUSIONS' named entity 'PREVIOUS' named entity 'INNATE IMMUNE RESPONSE' named entity 'TYPE' named entity 'CERTAIN' named entity 'METHODS' named entity 'KAWASAKI DISEASE' named entity 'EVALUATED' named entity 'RESULTS' named entity 'NOTED' named entity 'MODULATING' named entity 'TO INVESTIGATE' named entity 'STUDY' named entity 'CLEC5A' named entity 'TOTAL' named entity 'UNKNOWN ETIOLOGY' named entity 'POLYMORPHISMS' named entity 'ASSAY' named entity 'INVOLVED' named entity 'TREATMENT RESPONSE' named entity 'ASSOCIATION' named entity 'CANDIDATE GENES' named entity 'ASSESSED' named entity 'GENETIC' named entity 'STUDIES' named entity 'LACK' named entity '28381' named entity 'CHARACTERIZED' named entity 'CHI-SQUARE TEST' named entity 'FORMATION' named entity 'CHILDREN' named entity 'ASSOCIATION' named entity 'GENE' named entity 'EFFECTS' named entity 'SYSTEMIC VASCULITIS' named entity 'SIGNIFICANT' named entity 'DISEASE OUTCOME' named entity 'TIME' named entity 'TAGGING' named entity 'ASSOCIATED WITH' named entity 'AIM' named entity 'ALLELE FREQUENCY' named entity 'LECTIN' named entity 'OUTCOME' named entity 'HARDY-WEINBERG EQUILIBRIUM' named entity 'SUBJECTS' named entity 'TO IDENTIFY' named entity 'KAWASAKI DISEASE'

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