About: Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency

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About: Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency
Creator	Covarrubias, Sergio Clyde, Karen Coscoy, Laurent Glaunsinger, Britt Wang, Tina Pezda, Andrea Richner, Justin Renuka Kumar, G Cheng, Hin Yee, Benson
Source	PMC
abstract	During a lytic gammaherpesvirus infection, host gene expression is severely restricted by the global degradation and altered 3′ end processing of mRNA. This host shutoff phenotype is orchestrated by the viral SOX protein, yet its functional significance to the viral lifecycle has not been elucidated, in part due to the multifunctional nature of SOX. Using an unbiased mutagenesis screen of the murine gammaherpesvirus 68 (MHV68) SOX homolog, we isolated a single amino acid point mutant that is selectively defective in host shutoff activity. Incorporation of this mutation into MHV68 yielded a virus with significantly reduced capacity for mRNA turnover. Unexpectedly, the MHV68 mutant showed little defect during the acute replication phase in the mouse lung. Instead, the virus exhibited attenuation at later stages of in vivo infections suggestive of defects in both trafficking and latency establishment. Specifically, mice intranasally infected with the host shutoff mutant accumulated to lower levels at 10 days post infection in the lymph nodes, failed to develop splenomegaly, and exhibited reduced viral DNA levels and a lower frequency of latently infected splenocytes. Decreased latency establishment was also observed upon infection via the intraperitoneal route. These results highlight for the first time the importance of global mRNA degradation during a gammaherpesvirus infection and link an exclusively lytic phenomenon with downstream latency establishment.
has issue date	2011-07-21(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1002150
bibo:pmid	21811408
has license	cc-by
sha1sum (hex)	8ef53001824bab46d02f6968b8ee1a148a7406d9
schema:url	https://doi.org/10.1371/journal.ppat.1002150
resource representing a document's title	Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency
has PubMed Central identifier	PMC3141057
has PubMed identifier	21811408
schema:publication	PLoS Pathog
resource representing a document's body	covid:8ef53001824bab46d02f6968b8ee1a148a7406d9#body_text
is schema:about of	named entity 'levels' named entity 'capacity' named entity 'protein' named entity 'global' named entity 'viral' named entity 'virus' named entity 'phenotype' named entity 'frequency' named entity 'SOX' named entity 'latency' named entity 'PHENOTYPE' named entity 'DUE TO' named entity 'STAGES' named entity 'AMINO ACID' named entity 'INFECTION' named entity 'RESTRICTED' named entity 'TRAFFICKING' named entity 'LATER' named entity 'INTRAPERITONEAL ROUTE' named entity 'DEFECT' named entity 'SCREEN' named entity 'RESULTS' named entity 'ACUTE' named entity 'REPLICATION' named entity 'MURINE GAMMAHERPESVIRUS 68' named entity 'AT 10' named entity 'USING' named entity 'LEVELS' named entity 'IN VIVO' named entity 'CAPACITY' named entity 'LYMPH NODES' named entity 'DOWNSTREAM' named entity 'DAYS' named entity 'HOMOLOG' named entity 'SEVERELY' named entity 'GLOBAL' named entity 'HOST' named entity 'END' named entity 'ACTIVITY' named entity 'SOX' named entity 'TURNOVER' named entity 'MUTAGENESIS' named entity 'MRNA DEGRADATION' named entity 'PHENOMENON' named entity 'FAILED' named entity 'SINGLE' named entity 'INFECTED' named entity 'LINK' named entity 'ATTENUATION' named entity 'DEGRADATION' named entity 'TIME' named entity 'REDUCED' named entity 'GAMMAHERPESVIRUS' named entity 'MUTANT' named entity 'OBSERVED' named entity 'NATURE' named entity 'PROCESSING' named entity 'POST' named entity 'ACCUMULATED' named entity 'SUGGESTIVE OF' covid:arg/8ef53001824bab46d02f6968b8ee1a148a7406d9 named entity 'LOWER' named entity 'MRNA' named entity 'PHASE' named entity 'MUTATION' named entity 'SPLENOMEGALY' named entity 'DECREASED' named entity 'PROTEIN' named entity 'VIRAL DNA' named entity 'VIRAL' named entity 'SIGNIFICANCE' named entity 'VIRUS'

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