About: Differential expression analysis of the broiler tracheal proteins responsible for the immune response and muscle contraction induced by high concentration of ammonia using iTRAQ-coupled 2D LC-MS/MS

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About: Differential expression analysis of the broiler tracheal proteins responsible for the immune response and muscle contraction induced by high concentration of ammonia using iTRAQ-coupled 2D LC-MS/MS Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Differential expression analysis of the broiler tracheal proteins responsible for the immune response and muscle contraction induced by high concentration of ammonia using iTRAQ-coupled 2D LC-MS/MS
Creator	Xiong, Yan Tang, Xiangfang Zhang, Hongfu Sciences, Life Meng, Qingshi
topic	covid:8efde7fef6db7271b842bf15777bf739e2a5a32b#this
source	PMC
abstract	Ammonia has been considered the contaminant primarily responsible for respiratory disease in poultry. Even though it can cause tracheal lesions, its adverse effects on the trachea have not been sufficiently studied. The present study investigated tracheal changes in Arbor Acres broilers (Gallus gallus) induced by high concentration of ammonia using isobaric tag for relative and absolute quantification (iTRAQ)-based proteome analysis. In total, 3,706 proteins within false discovery rate of 1% were identified, including 119 significantly differentially expressed proteins. Functional analysis revealed that proteins related to immune response and muscle contraction were significantly enriched. With respect to the immune response, up-regulated proteins (like FGA) were pro-inflammatory, while down-regulated proteins participated in antigen processing and antigen presenting (like MYO1G), immunoglobulin and cathelicidin production (like fowlicidin-2), and immunodeficiency (like PTPRC). Regarding muscle contraction, all differentially expressed proteins (like TPM1) were up-regulated. An over-expression of mucin, which is a common feature of airway disease, was also observed. Additionally, the transcriptional alterations of 6 selected proteins were analyzed by quantitative RT-PCR. Overall, proteomic changes suggested the onset of airway obstruction and diminished host defense in trachea after ammonia exposure. These results may serve as a valuable reference for future interventions against ammonia toxicity. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s11427-016-0202-8 and is accessible for authorized users.
has issue date	2016-10-17(xsd:dateTime)
bibo:doi	10.1007/s11427-016-0202-8
bibo:pmid	27761697
has license	cc-by
sha1sum (hex)	8efde7fef6db7271b842bf15777bf739e2a5a32b
schema:url	https://doi.org/10.1007/s11427-016-0202-8
resource representing a document's title	Differential expression analysis of the broiler tracheal proteins responsible for the immune response and muscle contraction induced by high concentration of ammonia using iTRAQ-coupled 2D LC-MS/MS
has PubMed Central identifier	PMC7089013
has PubMed identifier	27761697
schema:publication	Sci China Life Sci
resource representing a document's body	covid:8efde7fef6db7271b842bf15777bf739e2a5a32b#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/8efde7fef6db7271b842bf15777bf739e2a5a32b
is schema:about of	named entity 'TRACHEAL' named entity 'proteins' named entity 'common' named entity 'immune response' named entity 'quantification' »more»

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