About: Characterization of a novel live attenuated infectious bronchitis virus vaccine candidate derived from a Korean nephropathogenic strain

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About: Characterization of a novel live attenuated infectious bronchitis virus vaccine candidate derived from a Korean nephropathogenic strain Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of a novel live attenuated infectious bronchitis virus vaccine candidate derived from a Korean nephropathogenic strain
Creator	Lee, Hyun Choi, In Kim, Jae Kwon, Ji Lee, Joong Lee, Youn Park, Yong Song, Chang Youn, Ha
source	Elsevier; Medline; PMC
abstract	Abstract A nephropathogenic K2/01 strain of infectious bronchitis virus (IBV) was attenuated by 170 serial passages in embryonated chicken eggs for possible use as a future IBV vaccine strain. High-growth properties and narrow tissue tropisms (limited replication in respiratory tracts) were achieved by the adaptation process. Unlike the parent strain, the attenuated strain (K2p170) was safe in day-old specific-pathogen-free chicks since replication of the virus did not induce mortality and nephritis, and rarely induced histological changes in the trachea and kidney after intraocular administration. In day-old broilers, even though coarse spray administration of K2p170 induced clinical signs, ciliostasis, and histopathological lesions in the trachea and the kidney, they were all comparable to birds vaccinated with commercial H120 vaccine. Despite restriction of viral replication in the respiratory tract, K2p170 elicited the production of antiserum with a neutralization index of 4.5. K2p170 provided almost complete protection against both two distinct subgroups of Korean nephropathogenic strain (KM91-like and QX-like subgroup). Furthermore, K2p170 provided significantly greater cross-protection against two heterologous strains (Massachusetts and Korean respiratory strain) than those conferred by the commercial H120 vaccine. K2p170 also had no virulence reversion after five back passages in chickens. In conclusion, K2p170 exhibits a fine balance between attenuation and immunogenicity, possesses cross-protective efficacy, and merits further investigation as a potential live vaccine as an alternative means of protection against the recently emergent nephropathogenic IBV infection in many Eurasian countries.
has issue date	2010-04-01(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2010.01.062
bibo:pmid	20153350
has license	els-covid
sha1sum (hex)	8f3fffb6a99b0baa471ddd963ee04bfa71e1bb97
schema:url	https://doi.org/10.1016/j.vaccine.2010.01.062
resource representing a document's title	Characterization of a novel live attenuated infectious bronchitis virus vaccine candidate derived from a Korean nephropathogenic strain
has PubMed Central identifier	PMC7125847
has PubMed identifier	20153350
schema:publication	Vaccine
resource representing a document's body	covid:8f3fffb6a99b0baa471ddd963ee04bfa71e1bb97#body_text
is schema:about of	named entity 'histopathological' named entity 'alternative' named entity 'reversion' named entity 'vaccinated' named entity 'STRAIN' named entity 'MORTALITY' named entity 'ALTERNATIVE' named entity 'HETEROLOGOUS' named entity 'CLINICAL SIGNS' named entity 'COUNTRIES' named entity 'FINE' named entity 'LIVE VACCINE' named entity 'VACCINE' named entity 'CHICKENS' named entity 'IMMUNOGENICITY' named entity 'COMMERCIAL' named entity 'TISSUE' named entity 'BIRDS' named entity 'VIRUS' named entity 'SERIAL' named entity 'RESPIRATORY TRACT' named entity 'REPLICATION' named entity 'ATTENUATION' named entity 'LIKE' named entity 'LESIONS' named entity 'SAFE' named entity 'INDUCED' named entity 'PRODUCTION' named entity 'EXHIBITS' named entity 'ANTISERUM' named entity 'COMPLETE' named entity 'MEANS' named entity 'TROPISMS' named entity 'DISTINCT' named entity 'KIDNEY' named entity 'DID' named entity 'ADAPTATION' named entity 'INVESTIGATION' named entity 'RARELY' named entity 'SUBGROUPS' named entity 'RESTRICTION' named entity 'INFECTIOUS BRONCHITIS VIRUS' covid:arg/8f3fffb6a99b0baa471ddd963ee04bfa71e1bb97 named entity 'KOREAN' named entity 'NOVEL' named entity 'LIVE' named entity 'CONCLUSION' named entity 'STRAIN' named entity 'CHICKS' named entity 'FUTURE' named entity 'RESPIRATORY' named entity 'EMERGENT' named entity 'VACCINATED' named entity 'ALMOST' named entity '170' named entity 'USE' named entity 'POSSIBLE' named entity 'BALANCE' named entity 'CROSS' named entity 'SUBGROUP' named entity 'GREATER' named entity 'CHICKEN' named entity 'POSSESSES' named entity 'INFECTION' named entity 'GROWTH' named entity 'EFFICACY' named entity 'RESPIRATORY TRACTS' named entity 'INFECTIOUS BRONCHITIS VIRUS VACCINE' named entity 'PARENT' named entity 'ATTENUATED BY' named entity 'DERIVED' named entity 'ATTENUATED' named entity 'CHARACTERIZATION'

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