About: The emergence of COVID-19 in Indonesia: analysis of predictors of infection and mortality using independent and clustered data approaches

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About: The emergence of COVID-19 in Indonesia: analysis of predictors of infection and mortality using independent and clustered data approaches Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The emergence of COVID-19 in Indonesia: analysis of predictors of infection and mortality using independent and clustered data approaches
Creator	Setiawaty, Vivi Agustina, Rina Burhan, Erlina Gede, I Guntara, Aswin Lestari, Dewi Lolong Wulung, Navy Ocviyanti, Dwiana Prasenohadi, Puspitorini, Dewi Putri, Kartika Rahyussalim, Ahmad Rianda, Davrina Sajinadiyasa, Ketut Shankar, Anuraj Susanto, Agus Syam, Ari Widyahening, Indah
Source	MedRxiv
abstract	Background: Analyses of correlates of SARS-CoV-2 infection or mortality have usually assessed individual predictors. This study aimed to determine if patterns of combined predictors may better identify risk of infection and mortality. Methods: For the period of March 2nd to 10th 2020, the first 9 days of the COVID-19 pandemic in Indonesia, we selected all 18 confirmed cases, of which 6 died, and all 60 suspected cases, of which 1 died; and 28 putatively negative patients with pneumonia and no travel history. We recorded data for travel, contact history, symptoms, haematology, comorbidities, and chest x-ray. Hierarchical cluster analyses (HCA) and principal component analyses (PCA) identified cluster and covariance patterns for symptoms or haematology which were analysed with other predictors of infection or mortality using logistic regression. Results: For univariate analyses, no significant association with infection was seen for fever, cough, dyspnoea, headache, runny nose, sore throat, gastrointestinal complaints (GIC), or haematology. A PCA symptom component for fever, cough, and GIC tended to increase risk of infection (OR 3.41; 95% CI 1.06 - 14; p=0.06), and a haematology component with elevated monocytes decreased risk (OR 0.26; 0.07 - 0.79; 0.027). Multivariate analysis revealed that an HCA cluster of 3-5 symptoms, typically fever, cough, headache, runny nose, sore throat but little dyspnoea and no GIC tended to reduce risk (aOR 0.048; <0.001 - 0.52; 0.056). In univariate analyses for death, an HCA cluster of cough, fever and dyspnoea had increased risk (OR 5.75; 1.06 - 31.3, 0.043), but no other individual predictor, cluster or component was associated. Other significant predictors of infection were age >= 45, international travel, contact with COVID-19 patient, and pneumonia. Diabetes and history of contact were associated with higher mortality. Conclusions: Cluster groups and co-variance patterns may be stronger correlates of SARS-CoV-2 infection than individual predictors. Comorbidities may warrant careful attention as would COVID-19 exposure levels.
has issue date	2020-07-11(xsd:dateTime)
bibo:doi	10.1101/2020.07.10.20147942
has license	medrxiv
sha1sum (hex)	8f59418a584a3c076679bb7a5b5cc6695f6c135b
schema:url	https://doi.org/10.1101/2020.07.10.20147942
resource representing a document's title	The emergence of COVID-19 in Indonesia: analysis of predictors of infection and mortality using independent and clustered data approaches
resource representing a document's body	covid:8f59418a584a3c076679bb7a5b5cc6695f6c135b#body_text
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