About: Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
Creator	Toptas, Orcun Uzun, Tuğçenur
Source	Medline; PMC
abstract	SARS (Severe Acute Respiratory Syndrome Coronavirus)-CV-2 (2019-nCov), which showed up in China in December 2019 and spread all over the world, has becomed a serious health problem. An effective, safe and proven treatment has not yet been found. Chloroquine has been recommended by some authors to be used for the treatment of patients infected with this virus however chloroquine may have side effects and drug resistance problems. Artesunate is a semisynthetic derivative of artemisinin, an antimalarial drug. Artesunate was thought to be an effective treatment for covid-19 because of its anti-inflammatory activity, NF-κB (nuclear Factor kappa B)-coronavirus effect and chloroquine-like endocytosis inhibition mechanism.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.1186/s13020-020-00336-8
bibo:pmid	32514287
has license	cc-by
sha1sum (hex)	8fae13373b694102fe1b55d5bc596704ac36c7f5
schema:url	https://doi.org/10.1186/s13020-020-00336-8
resource representing a document's title	Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
has PubMed Central identifier	PMC7254722
has PubMed identifier	32514287
schema:publication	Chin Med
resource representing a document's body	covid:8fae13373b694102fe1b55d5bc596704ac36c7f5#body_text
is schema:about of	named entity 'activity' named entity 'chloroquine' named entity '2019' named entity 'MECHANISM' named entity 'Chloroquine' named entity 'Artesunate' named entity 'endocytosis' named entity 'side effects' named entity 'SARS' named entity 'nuclear Factor' named entity 'health problem' named entity 'endocytosis' named entity 'chloroquine' named entity 'treatment of patients' named entity 'COVID-19' named entity 'SARS-Cov-2' named entity 'virus' named entity 'TNF-α' named entity 'Artesunate' named entity 'MERS-CoV' named entity 'coronavirus' named entity 'TGF-β' named entity 'IL-1β' named entity 'nucleus' named entity 'immune response' named entity 'proinflammatory cytokines' named entity 'chemokines' named entity 'Artemisia annua' named entity 'JC polyomavirus' named entity 'NF-κB' named entity 'SARS-CoV-2' named entity 'interleukin 8' named entity 'Kaptein' named entity 'chloroquine' named entity 'Coronavirus' named entity 'IL-10' named entity 'enveloped viruses' named entity 'human coronaviruses' named entity 'hepatitis' named entity 'semisynthetic' named entity 'MERS-CoV' named entity 'endocytosis' named entity '2019-nCov' named entity 'IFN' named entity 'NF-κB' named entity 'artesunate' named entity 'IL-6' named entity 'China' named entity 'IL-6' named entity 'SARS-CoV-2' named entity 'NF-κB' named entity 'anti-inflammatory' named entity 'MCP-1' named entity 'immunomodulatory' named entity 'IFN' named entity 'antimalarials' named entity 'anti-inflammatory' named entity 'serum' named entity 'inflammatory response' named entity 'protein' named entity 'inflammatory response' named entity 'interferon' named entity 'protein' named entity 'secretion' named entity 'health problem' named entity 'IL-6' named entity 'IL-7' named entity 'NF-κB' named entity 'adaptive immune responses' named entity 'immune response' named entity 'Artemisinin' named entity 'rheumatoid arthritis' named entity 'interleukin 10' named entity 'chloroquine' named entity 'SARS-CoV' named entity 'biomarker' named entity 'IL-1β' named entity 'IP-10' named entity 'immune response' named entity 'artemisinin'

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