About: Generating genomic platforms to study Candida albicans pathogenesis

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About: Generating genomic platforms to study Candida albicans pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Generating genomic platforms to study Candida albicans pathogenesis
Creator	Arbogast, Laurence Bachellier-Bassi, Sophie Bouchier, Christiane Boyer, Hélène Cabral, Vitor Chaudhari, Yogesh Chauvel, Murielle Legrand, Mélanie Ma, Laurence Majgier, Charlotte Maslanka, Irena Maufrais, Corinne Nesseir, Audrey Permal, Emmanuelle Rossignol, Tristan Schoeters, Floris Tichit, Magali Tournu, Hélène Zeidler, Ute Znaidi, Sadri D'enfert, Christophe Dijck, Patrick Julien, Renaud Laboratoire D'immunologie, Henri Lee, Keunsook Mondor, Munro, Carol Walker, Louise Znaidi, Austria
source	PMC
abstract	The advent of the genomic era has made elucidating gene function on a large scale a pressing challenge. ORFeome collections, whereby almost all ORFs of a given species are cloned and can be subsequently leveraged in multiple functional genomic approaches, represent valuable resources toward this endeavor. Here we provide novel, genome-scale tools for the study of Candida albicans, a commensal yeast that is also responsible for frequent superficial and disseminated infections in humans. We have generated an ORFeome collection composed of 5099 ORFs cloned in a Gateway™ donor vector, representing 83% of the currently annotated coding sequences of C. albicans. Sequencing data of the cloned ORFs are available in the CandidaOrfDB database at http://candidaorfeome.eu. We also engineered 49 expression vectors with a choice of promoters, tags and selection markers and demonstrated their applicability to the study of target ORFs transferred from the C. albicans ORFeome. In addition, the use of the ORFeome in the detection of protein–protein interaction was demonstrated. Mating-compatible strains as well as Gateway™-compatible two-hybrid vectors were engineered, validated and used in a proof of concept experiment. These unique and valuable resources should greatly facilitate future functional studies in C. albicans and the elucidation of mechanisms that underlie its pathogenicity.
has issue date	2018-08-21(xsd:dateTime)
bibo:doi	10.1093/nar/gky594
bibo:pmid	29982705
has license	cc-by
sha1sum (hex)	8fc0e17fe32585f3e3216b48c7beba4b15221e57
schema:url	https://doi.org/10.1093/nar/gky594
resource representing a document's title	Generating genomic platforms to study Candida albicans pathogenesis
has PubMed Central identifier	PMC6101633
has PubMed identifier	29982705
schema:publication	Nucleic Acids Res
resource representing a document's body	covid:8fc0e17fe32585f3e3216b48c7beba4b15221e57#body_text
is schema:about of	named entity 'USED' named entity 'SELECTION MARKERS' named entity 'USE OF' named entity 'COLLECTION' named entity 'SPECIES' named entity 'SEQUENCES' named entity 'THESE' named entity 'REPRESENT' named entity 'GIVEN' named entity 'EXPRESSION VECTORS' named entity 'STUDIES' named entity 'TAGS' named entity 'CANDIDA ALBICANS' named entity 'RESOURCES' named entity 'GENERATED' named entity 'COLLECTIONS' named entity 'ALMOST ALL' named entity 'FUTURE' named entity 'CODING' named entity 'FREQUENT' named entity 'SUPERFICIAL' named entity 'MATING' named entity 'large' named entity 'multiple' named entity 'Candida' named entity 'PATHOGENICITY' named entity 'COMPOSED OF' named entity 'TARGET' named entity 'VALIDATED' named entity 'APPROACHES' named entity 'COMPATIBLE' named entity 'STUDY' named entity 'PROOF OF CONCEPT' named entity 'PROTEIN-PROTEIN INTERACTION' named entity 'COMMENSAL' named entity 'FUNCTIONAL GENOMIC' named entity 'LARGE SCALE' named entity 'FUNCTIONAL' named entity 'EXPERIMENT' named entity 'GENOME' named entity 'TWO-HYBRID' named entity 'DISSEMINATED' named entity 'CLONED' named entity 'PRESSING' named entity 'AVAILABLE' named entity 'CANDIDA ALBICANS' named entity 'PATHOGENESIS' named entity 'GENOMIC' named entity 'NAR' named entity 'BREAKTHROUGH' named entity 'STUDY' named entity 'ADDITION' named entity 'UNIQUE'

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