About: The Pharmacokinetic and Pharmacodynamic Properties of Hydroxychloroquine and Dose Selection for COVID-19: Putting the Cart Before the Horse

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About: The Pharmacokinetic and Pharmacodynamic Properties of Hydroxychloroquine and Dose Selection for COVID-19: Putting the Cart Before the Horse Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Pharmacokinetic and Pharmacodynamic Properties of Hydroxychloroquine and Dose Selection for COVID-19: Putting the Cart Before the Horse
Creator	Francisco, San Michael, J Goswami Insightrx, S Jason, M Lodise, P Lodise, T Marc, H Pogue, Pogue, J Rybak, Rybak, M Scheetz, Scheetz, M Srijib, Goswami Thomas, Taylor
source	Medline; PMC
abstract	Coronavirus disease 2019 (COVID-19), caused by the 2019 novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently responsible for a global pandemic. To date, only remdesivir and dexamethasone have demonstrated a positive response in a prospective, randomized trial for the treatment of patients with COVID-19. Hydroxychloroquine (HCQ) is an agent available in an oral formulation with in vitro activity against SARS-CoV-2 that has been suggested as a potential agent. Unfortunately, results of randomized trials evaluating HCQ as treatment against a control group are lacking, and little is known about its pharmacokinetic/pharmacodynamic (PK/PD) profile against SARS-CoV-2. The objective of this review was to describe the current understanding of the PK/PD and dose selection of HCQ against SARS-CoV-2, discuss knowledge gaps, and identify future studies that are needed to optimize the efficacy and safety of treatments against COVID-19.
has issue date	2020-08-01(xsd:dateTime)
bibo:doi	10.1007/s40121-020-00325-2
bibo:pmid	32740858
has license	cc-by-nc
sha1sum (hex)	8fd0d5b9753e4677571e37c2222891179a4e0669
schema:url	https://doi.org/10.1007/s40121-020-00325-2
resource representing a document's title	The Pharmacokinetic and Pharmacodynamic Properties of Hydroxychloroquine and Dose Selection for COVID-19: Putting the Cart Before the Horse
has PubMed Central identifier	PMC7395206
has PubMed identifier	32740858
schema:publication	Infect Dis Ther
resource representing a document's body	covid:8fd0d5b9753e4677571e37c2222891179a4e0669#body_text
is schema:about of	named entity 'remdesivir' named entity 'randomized trials' named entity 'response' named entity 'Hydroxychloroquine' named entity 'objective' named entity 'profile' named entity 'describe' named entity 'prospective' named entity 'control group' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Coronavirus disease 2019' named entity 'HCQ' named entity 'pharmacokinetic' named entity 'global pandemic' named entity 'pharmacodynamic' named entity 'PK/PD' named entity 'Hydroxychloroquine' named entity 'Pharmacodynamic' named entity 'lysosomal' named entity 'antimicrobials' named entity 'racemic' named entity 'monotherapy' named entity 'prophylaxis' named entity 'Post-exposure prophylaxis' named entity 'organic anion transporting polypeptide' named entity 'adverse effect' named entity 'HCQ' named entity 'endosomes' named entity 'CYP' named entity 'Antiviral' named entity 'HCQ' named entity 'chloroquine' named entity 'stereoselective' named entity 'COVID-19' named entity 'post-exposure prophylaxis' named entity 'glycosylation' named entity 'monotherapy' named entity 'chloroquine' named entity 'COVID-19' named entity 'membrane transporters' named entity 'PBPK' named entity 'HCQ' named entity 'HCQ' named entity 'mechanical ventilation' named entity 'pharmacodynamic' named entity 'COVID-19' named entity 'antimalarial agent' named entity 'HCQ' named entity 'HCQ' named entity 'COVID' named entity 'immunomodulatory' named entity 'COVID' named entity 'HCQ' named entity 'chloroquine' named entity 'supportive care' named entity 'QTc prolongation' named entity 'chloroquine' named entity 'airway' named entity 'HCQ' named entity 'HCQ' named entity 'HCQ' named entity 'adverse effects' named entity 'HCQ' named entity 'HCQ' named entity 'receptor' named entity 'serum'

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