About: Infectious Lung Diseases and Endogenous Oxidative Stress

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Infectious Lung Diseases and Endogenous Oxidative Stress Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infectious Lung Diseases and Endogenous Oxidative Stress
Creator	Sarkar, Kasturi Sil, Parames Sarkar, K Sil, P
Source	PMC
abstract	Lower respiratory tract infections, according to the World Health Organization, account for nearly one third of all deaths from infectious diseases. They account for approximately 4 million deaths annually including children and adults and provide a greater disease burden than HIV and malaria. Among the common respiratory diseases, tuberculosis, influenza, and pneumonia are very common and can be life threatening if not treated properly. The causative agent of tuberculosis is the slow-growing bacilli Mycobacterium tuberculosis, while the causative agent of influenza is a segmented genome RNA virus. Pneumonia can be caused by a number of different microorganisms like bacteria, virus, and mycoplasma. In case of the entry of a pathogen in our body, the immune system gets activated, and the phagocytic cells try to eliminate it by generating reactive oxygen and nitrogen species (ROS and RNS) inside the phagosome. These reactive species or respiratory bursts are sufficient to eliminate most of the pathogens, except a few. M. tuberculosis is one such microorganism that has evolved mechanisms to escape this respiratory burst-mediated killing and thus survive and grow inside the macrophages. Infection with M. tuberculosis leads to the destruction of macrophages and release of cytokines, which lead to prolonged immune activation and oxidative stress. In some cases, the bacilli remain dormant inside macrophages for a long time. Flu viruses infect the epithelial cells present in respiratory tract, and the infection site is dependent on the hemagglutinin protein present on their capsid. Destruction of epithelial cells promotes secretion of mucus and activation of immune system leading to the oxidative damage. Community-acquired pneumonia is more serious and difficult to treat. In all these infections, ROS/RNS are developed as a defense mechanism against the pathogen. Persistence of the pathogen for a long time would lead to the uncontrolled production of ROS/RNS which will lead to oxidative stress and tissue damage to the host. Administration of antioxidants along with conventional treatments can be useful in the elimination of the reactive oxygen and nitrogen species.
has issue date	2019-05-02(xsd:dateTime)
bibo:doi	10.1007/978-981-13-8413-4_7
has license	no-cc
sha1sum (hex)	8fdb9dc549365f6886433fc9ee36cb5c7c0016cd
schema:url	https://doi.org/10.1007/978-981-13-8413-4_7
resource representing a document's title	Infectious Lung Diseases and Endogenous Oxidative Stress
has PubMed Central identifier	PMC7122037
schema:publication	Oxidative Stress in Lung Diseases
resource representing a document's body	covid:8fdb9dc549365f6886433fc9ee36cb5c7c0016cd#body_text
is schema:about of	named entity 'Diseases' named entity 'hepatotoxicity' named entity 'opsonization' named entity 'neutrophils' named entity 'fever' named entity 'LPS' named entity 'pulmonary tuberculosis' named entity 'macrophage' named entity 'mice' named entity 'conjugate vaccines' named entity 'defense mechanism' named entity 'Sia' named entity 'GSSG' named entity 'slow-growing' named entity 'superoxide radical' named entity 'mice' named entity 'Murine' named entity 'neutrophil' named entity 'infection' named entity 'superoxides' named entity 'mucus' named entity 'calcineurin' named entity 'macrophages' named entity 'sepsis' named entity 'adjuvant therapy' named entity 'flu' named entity 'coughing' named entity 'microorganisms' named entity 'Influenza viruses' named entity 'mummies' named entity 'microscope' named entity 'immune responses' named entity 'viruses' named entity 'H7N9' named entity 'acid phosphatase' named entity 'community-acquired' named entity 'granulomas' named entity 'neutrophils' named entity 'protein' named entity 'microorganisms' named entity 'tuberculosis' named entity 'bacterial pneumonia' named entity 'antioxidants' named entity 'MCP-1' named entity 'Streptococcus pneumoniae' named entity 'Pneumonia' named entity 'loss of appetite' named entity 'leukocyte count' named entity 'Staphylococcus aureus' named entity 'cation channel' named entity 'Southeast Asia' named entity 'cytokines' named entity 'CXCL6' named entity 'IAV' named entity 'Neutrophil' named entity 'erythrocyte aggregation' named entity 'cough' named entity 'loss of weight' named entity 'plasma' named entity 'redox' named entity 'anti-influenza' named entity 'virus' named entity 'High levels' named entity 'vaccine' named entity 'polyunsaturated fatty acids' named entity 'antioxidants' named entity 'Africa' named entity 'ROS' named entity 'antioxidants' named entity 'dead host cells' named entity 'Morens' named entity 'dendritic cells' named entity 'flu' named entity 'titer' named entity 'IL-2' named entity 'macrophages' named entity 'M2 protein' named entity 'respiratory illness' named entity 'developing countries' named entity 'protein'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software