About: CLINICAL COURSE, RISK FACTORS FOR TRANSFER TO ICU AND MORTALITY IN PATIENTS WITH COVID-19 AFFECTED BY ACUTE RESPIRATORY FAILURE REFERRED TO A RESPIRATORY INTERMEDIATATE CARE UNIT.

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About: CLINICAL COURSE, RISK FACTORS FOR TRANSFER TO ICU AND MORTALITY IN PATIENTS WITH COVID-19 AFFECTED BY ACUTE RESPIRATORY FAILURE REFERRED TO A RESPIRATORY INTERMEDIATATE CARE UNIT. Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CLINICAL COURSE, RISK FACTORS FOR TRANSFER TO ICU AND MORTALITY IN PATIENTS WITH COVID-19 AFFECTED BY ACUTE RESPIRATORY FAILURE REFERRED TO A RESPIRATORY INTERMEDIATATE CARE UNIT.
Creator	Resta, Onofrio Carpagnano, Giovanna Boniello, Esterina Buonamico, Enrico Capozza, Elena Dimitri, Michela Labate, Luciana Majorano, Marco Pierucci, Paola Quaranta, Vitaliano
Source	MedRxiv
abstract	Introduction There are no clear guidelines as yet for the selection of patients affected by COVID-19 who can be treated in intermediate RICU, neither shared criteria for their intubation and transfer in ICU. In the present study we described the clinical course and risk factors for transfer to ICU and mortality of SARS-Cov-2 positive patients affected by acute respiratory failure, hospitalized in a Respiratory Intermediate Care Unit in the south of Italy. Methods In this retrospective, observational single centre study we evaluated 96 laboratory confirmed COVID-19 patients affected by acute respiratory failure (ARF). We compared demographic data, laboratory data and clinical outcomes between deceased and survived patients, aiming to identify risk factors for transfer to ICU and mortality, and possible gender-related differences. Results Of 96 patients, 51 (53.1%) survived and 45 (46.9 %) died. Among those who died, 23 (51.1%) deceased in RICU. Twenty-nine (30.2%) were transferred to ICU, of whom 22 (75.9%) died in ICU. Patients affected by COPD have a higher mortality compared to patients without this comorbidity (p=0.002). Lower baseline P/F ratio (p=0,014) and neurologic comorbidities (p=0,008) emerged as risk factors for death. Male were younger than female patients (66 vs 80 y.o.; p=0.042). In female patients, lower peripheral blood lymphocyte count (p=0.007) is a risk factor for death, characteristic gender-related in our sample. Female sex was a protective parameter against transfer to ICU (p=0,036) and P/F ratio was not a significant predictor of transfer to ICU (p=0,227). Only higher baseline CRP (p=0,034) has shown a predictive role for transfer to ICU in our sample. Patients deceased after a transfer to ICU had younger age (p=0,000), lower median comorbidity number (p=0,000), lower D-dimer (p=0,029) and lower prevalence of female sex (p=0,029). Discussion Mortality in our study was similar to that found in other studies involving patients in non-invasive ventilation. In our study older age and comorbidities play as predictors of death in COVID-19 patients. COPD, despite presenting low prevalence, is a risk factor for death, both in men and women. In female patients chronic ischemic heart disease and congestive heart failure are death predictors. High CRP and lymphopenia, linked to inflammatory status, are predictors of transfer to ICU. Patients transferred to ICU higher mortality than the others, and patients who die in ICU are mostly men, younger and have less comorbidities. Baseline P/F ratio is not a good predictor of transfer to ICU, while in our sample is a sensible predictor of death. More studies need to be performed on COVID-19 patients, in the urgency of COVID-19 pandemic persistence.
has issue date	2020-08-22(xsd:dateTime)
bibo:doi	10.1101/2020.08.19.20178350
has license	medrxiv
sha1sum (hex)	8fe6c4c4f752d688c9dd362403638fd5924f072b
schema:url	https://doi.org/10.1101/2020.08.19.20178350
resource representing a document's title	CLINICAL COURSE, RISK FACTORS FOR TRANSFER TO ICU AND MORTALITY IN PATIENTS WITH COVID-19 AFFECTED BY ACUTE RESPIRATORY FAILURE REFERRED TO A RESPIRATORY INTERMEDIATATE CARE UNIT.
resource representing a document's body	covid:8fe6c4c4f752d688c9dd362403638fd5924f072b#body_text
is schema:about of	named entity 'treated' named entity 'COVID-19' named entity 'TRANSFER' named entity 'NEITHER' named entity 'COVID-19' named entity 'SELECTION' named entity 'COVID' named entity 'comorbidities' named entity 'ICU' named entity 'survival analysis' named entity 'polymerase chain reaction' named entity 'univariate analysis' named entity 'ICU' named entity 'metabolic' named entity 'preprint' named entity 'lymphocytes' named entity 'acute respiratory failure' named entity 'HR 2' named entity 'Charlson Comorbidity Index' named entity 'hypertension' named entity 'preprint' named entity 'congestive heart failure' named entity 'preprint' named entity 'medRxiv' named entity 'There' named entity 'neurological' named entity 'pharmacologic' named entity 'ICU' named entity 'respiratory failure' named entity 'lung' named entity 'D-Dimer' named entity 'COVID' named entity 'COVID' named entity 'mortality risk' named entity 'COPD' named entity 'congestive heart failure' named entity 'CRP' named entity 'older age' named entity 'high-throughput sequencing' named entity 'LDH' named entity 'ICU' named entity 'older age' named entity 'comorbidity' named entity 'comorbidities' named entity 'ICU' named entity 'COVID-19' named entity 'COVID' named entity 'ICU' named entity 'RISK' named entity 'COVID-19' named entity 'ACUTE RESPIRATORY FAILURE' named entity 'pathogenetic' named entity 'neurodegenerative disorders' named entity 'normal distribution' named entity '1,001' named entity 'CRP' named entity 'medRxiv' named entity 'ICU' named entity 'ICU' named entity 'renal failure' named entity 'ARF' named entity 'older age' named entity 'emergency condition' named entity 'significance level' named entity 'renal failure' named entity 'ARDS' named entity 'comorbidities' named entity 'atrial fibrillation' named entity 'preprint' named entity 'independent variables' named entity 'ICU' named entity 'ICU' named entity 'asymptomatic infection' named entity 'ICU' named entity 'ICU beds' named entity 'medical records'

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