About: Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes

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About: Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes
Creator	Prosperi, Mattia Lednicky, John Salemi, Marco Mavian, Carla Kang, Seokyoung Baumgartner, Caleb Boyles, Sean Buckner, Eva Dinglasan, Rhoel Finol, Esteban Geesey, Mary Hamerlinck, Gabriela Mai, Volker Mathias, Derrick Rivers, Adam Stephenson, Caroline Stinton, Israel Ukhanova, Maria Ja, Lednicky Williams, Katie Ar, Rivers Boyles, Citation Cj, Stephenson Cn, Mavian Dk, Mathias Ea, Buckner Kang, Hamerlinck Prosperi, M
Source	PMC
abstract	The incidence of locally acquired dengue infections increased during the last decade in the United States, compelling a sustained research effort concerning the dengue mosquito vector, Aedes aegypti, and its microbiome, which has been shown to influence virus transmission success. We examined the “metavirome” of four populations of Aedes aegypti mosquitoes collected in 2016 to 2017 in Manatee County, FL. Unexpectedly, we discovered that dengue virus serotype 4 (DENV4) was circulating in these mosquito populations, representing the first documented case of such a phenomenon in the absence of a local DENV4 human case in this county over a 2-year period. We confirmed that all of the mosquito populations carried the same DENV4 strain, assembled its full genome, validated infection orthogonally by reverse transcriptase PCR, traced the virus origin, estimated the time period of its introduction to the Caribbean region, and explored the viral genetic signatures and mosquito-specific virome associations that potentially mediated DENV4 persistence in mosquitoes. We discuss the significance of prolonged maintenance of the DENV4 infections in A. aegypti that occurred in the absence of a DENV4 human index case in Manatee County with respect to the inability of current surveillance paradigms to detect mosquito vector infections prior to a potential local outbreak. IMPORTANCE Since 1999, dengue outbreaks in the continental United States involving local transmission have occurred only episodically and only in Florida and Texas. In Florida, these episodes appear to be coincident with increased introductions of dengue virus into the region through human travel and migration from countries where the disease is endemic. To date, the U.S. public health response to dengue outbreaks has been largely reactive, and implementation of comprehensive arbovirus surveillance in advance of predictable transmission seasons, which would enable proactive preventative efforts, remains unsupported. The significance of our finding is that it is the first documented report of DENV4 transmission to and maintenance within a local mosquito vector population in the continental United States in the absence of a human case during two consecutive years. Our data suggest that molecular surveillance of mosquito populations in high-risk, high-tourism areas of the United States may enable proactive, targeted vector control before potential arbovirus outbreaks.
has issue date	2020-04-29(xsd:dateTime)
bibo:doi	10.1128/msphere.00316-20
bibo:pmid	32350095
has license	no-cc
sha1sum (hex)	9011eb415cf4a9be661570efdfe93dc73dce3d64
schema:url	https://doi.org/10.1128/msphere.00316-20
resource representing a document's title	Under-the-Radar Dengue Virus Infections in Natural Populations of Aedes aegypti Mosquitoes
has PubMed Central identifier	PMC7193045
has PubMed identifier	32350095
schema:publication	mSphere
resource representing a document's body	covid:9011eb415cf4a9be661570efdfe93dc73dce3d64#body_text
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