About: Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization
Creator	Ackerson, Bradley Skarbinski, Jacek Caparosa, Susan Fischer, Heidi Hong, Vennis Li, Zhuoxin Murali, Sameer Nadjafi, Ron Naik, Tej Nau, Claudia Qian, Lei Rieg, Gunter Saxena, Tanmai Sharp, Adam Shaw, Sally Tartof, Sara Wei, Rong
source	Medline; PMC
abstract	BACKGROUND: Obesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)–associated outcomes, yet studies have not adequately disentangled their effects. OBJECTIVE: To determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19. DESIGN: Retrospective cohort study. SETTING: Kaiser Permanente Southern California, a large integrated health care organization. PATIENTS: Kaiser Permanente Southern California members diagnosed with COVID-19 from 13 February to 2 May 2020. MEASUREMENTS: Multivariable Poisson regression estimated the adjusted effect of BMI and other factors on risk for death at 21 days; models were also stratified by age and sex. RESULTS: Among 6916 patients with COVID-19, there was a J-shaped association between BMI and risk for death, even after adjustment for obesity-related comorbidities. Compared with patients with a BMI of 18.5 to 24 kg/m(2), those with BMIs of 40 to 44 kg/m(2) and greater than 45 kg/m(2) had relative risks of 2.68 (95% CI, 1.43 to 5.04) and 4.18 (CI, 2.12 to 8.26), respectively. This risk was most striking among those aged 60 years or younger and men. Increased risk for death associated with Black or Latino race/ethnicity or other sociodemographic characteristics was not detected. LIMITATION: Deaths occurring outside a health care setting and not captured in membership files may have been missed. CONCLUSION: Obesity plays a profound role in risk for death from COVID-19, particularly in male patients and younger populations. Our capitated system with more equalized health care access may explain the absence of effect of racial/ethnic and socioeconomic disparities on death. Our data highlight the leading role of severe obesity over correlated risk factors, providing a target for early intervention. PRIMARY FUNDING SOURCE: Roche–Genentech.
has issue date	2020-08-12(xsd:dateTime)
bibo:doi	10.7326/m20-3742
bibo:pmid	32783686
has license	no-cc
sha1sum (hex)	90e091924c423270d31f046f2a13b1bb5f090faf
schema:url	https://doi.org/10.7326/m20-3742
resource representing a document's title	Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization
has PubMed Central identifier	PMC7429998
has PubMed identifier	32783686
schema:publication	Ann Intern Med
resource representing a document's body	covid:90e091924c423270d31f046f2a13b1bb5f090faf#body_text
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