About: High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice

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About: High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice
Creator	Ashraf, Shadma Mishra, Samir Sawant, Rakesh Shahnawaz, Satish Singh, P Tuli, Yadav, Dinesh
Source	Elsevier; Medline; PMC
abstract	Abstract A synthetic gene coding for the surface glycoprotein (G protein) of rabies virus was strategically designed to achieve high-level expression in transgenic plants. The native signal peptide was replaced by that of the pathogenesis related protein, PR-S of Nicotiana tabacum. An endoplasmic reticulum retention signal was included at C-terminus of the G protein. Tobacco plants were genetically engineered by nuclear transformation. Selected transgenic lines expressed the chimeric G protein at 0.38% of the total soluble leaf protein. Mice immunized intraperitoneally with the G protein purified from tobacco leaf microsomal fraction elicited high level of immune response as compared to the inactivated commercial viral vaccine. The plant-derived G protein induced complete protective immunity in mice against intracerebral lethal challenge with live rabies virus. The results establish that plants can provide a safe and effective production system for the expression of immunoprotective rabies virus surface protein.
has issue date	2005-09-22(xsd:dateTime)
bibo:doi	10.1016/j.jbiotec.2005.06.009
bibo:pmid	16038998
has license	els-covid
sha1sum (hex)	90f0782ba59a0051c0fa568cb23e8eec2e5f0e6c
schema:url	https://doi.org/10.1016/j.jbiotec.2005.06.009
resource representing a document's title	High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice
has PubMed Central identifier	PMC7114349
has PubMed identifier	16038998
schema:publication	Journal of Biotechnology
resource representing a document's body	covid:90f0782ba59a0051c0fa568cb23e8eec2e5f0e6c#body_text
is schema:about of	named entity 'IMMUNOPROTECTIVE' named entity 'MICE' named entity 'ITS' named entity 'RESULTS' named entity 'HIGH LEVEL' named entity '28G' named entity 'CODING' named entity 'PROTEIN ' named entity 'INDUCED' named entity 'PURIFIED' named entity 'SELECTED' named entity 'ENDOPLASMIC RETICULUM RETENTION SIGNAL' named entity 'COMPLETE' named entity 'LIVE' named entity 'INACTIVATED' named entity 'SYNTHETIC GENE' named entity 'EXPRESSION' named entity 'G PROTEIN' named entity 'COMPARED' named entity 'C-TERMINUS' named entity 'SAFE' named entity 'protein' named entity 'complete' named entity 'designed' named entity 'SURFACE GLYCOPROTEIN' named entity 'ACTIVITY' named entity 'ELICITED' named entity 'COMMERCIAL' named entity 'EXPRESSED' named entity 'LEAF PROTEIN' named entity 'LEAVES' named entity 'EXPRESSION' named entity 'CHALLENGE' named entity 'CHIMERIC' named entity 'IMMUNIZED' named entity 'TRANSGENIC PLANTS' named entity 'PLANT-' named entity 'SOLUBLE' named entity 'GENETICALLY ENGINEERED' named entity 'MICE' named entity 'NATIVE' named entity 'TOBACCO' named entity 'RABIES VIRUS' named entity 'ESTABLISH' named entity 'PROTECTIVE IMMUNITY' named entity 'RABIES VIRUS' named entity 'VIRAL VACCINE' named entity 'IMMUNOPROTECTIVE' named entity 'REPLACED BY' named entity 'PROVIDE' named entity 'RELATED' named entity 'DERIVED' named entity 'PRODUCTION' named entity 'PR-' named entity 'TRANSGENIC' named entity 'TOTAL' named entity 'LETHAL' named entity 'HIGH LEVEL' named entity 'TOBACCO' named entity 'HIGHLEVEL' named entity 'INTRACEREBRAL' named entity 'INCLUDED' named entity '0.38' named entity 'NICOTIANA TABACUM' named entity 'PROTEIN' named entity 'LINES' named entity 'SYSTEM' named entity 'EFFECTIVE' named entity 'SIGNAL PEPTIDE' named entity 'SURFACE PROTEIN' named entity 'FRACTION' named entity 'PATHOGENESIS' named entity 'MICROSOMAL' named entity 'IMMUNE RESPONSE' named entity 'NUCLEAR TRANSFORMATION'

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