About: Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System
Creator	Huang, Yu Gollasch, Maik Abu Bakar, Hamidah Kwong Cheng, Chak
Source	PMC
abstract	Perivascular adipose tissue (PVAT) refers to the local aggregate of adipose tissue surrounding the vascular tree, exhibiting phenotypes from white to brown and beige adipocytes. Although PVAT has long been regarded as simply a structural unit providing mechanical support to vasculature, it is now gaining reputation as an integral endocrine/paracrine component, in addition to the well-established modulator endothelium, in regulating vascular tone. Since the discovery of anti-contractile effect of PVAT in 1991, the use of multiple rodent models of reduced amounts of PVAT has revealed its regulatory role in vascular remodeling and cardiovascular implications, including atherosclerosis. PVAT does not only release PVAT-derived relaxing factors (PVRFs) to activate multiple subsets of endothelial and vascular smooth muscle potassium channels and anti-inflammatory signals in the vasculature, but it does also provide an interface for neuron-adipocyte interactions in the vascular wall to regulate arterial vascular tone. In this review, we outline our current understanding towards PVAT and attempt to provide hints about future studies that can sharpen the therapeutic potential of PVAT against cardiovascular diseases and their complications.
has issue date	2018-08-31(xsd:dateTime)
bibo:doi	10.1007/s10557-018-6820-z
bibo:pmid	30171461
has license	no-cc
sha1sum (hex)	91202be775965e6ef77500b26d4c6207d991a39b
schema:url	https://doi.org/10.1007/s10557-018-6820-z
resource representing a document's title	Perivascular Adipose Tissue: the Sixth Man of the Cardiovascular System
has PubMed Central identifier	PMC7101924
has PubMed identifier	30171461
schema:publication	Cardiovasc Drugs Ther
resource representing a document's body	covid:91202be775965e6ef77500b26d4c6207d991a39b#body_text
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