About: A risk-assessment model to rate the occurrence and relevance of adventitious agents in the production of influenza vaccines

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About: A risk-assessment model to rate the occurrence and relevance of adventitious agents in the production of influenza vaccines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A risk-assessment model to rate the occurrence and relevance of adventitious agents in the production of influenza vaccines
Creator	Gregersen, Jens-Peter
Source	Elsevier; Medline; PMC
abstract	Abstract Influenza vaccine production has traditionally relied on the use of embryonated chicken eggs for virus isolation and propagation, but recently, cell-culture-derived manufacturing methods have been introduced. During influenza vaccine production, by either conventional or cell culture methods, there is a risk of incidental contamination by adventitious agents. Thus, a risk-assessment model has been developed to qualitatively assess the potential risk of vaccine process contamination by viral pathogens. The model takes into account the basic growth characteristics of each virus, its ability to grow in different cell substrates and resistance to processing steps during vaccine manufacture. The risk-assessment model has been applied to various pathogens to determine potential risk and relevance in different manufacturing scenarios, using different cell substrates for virus propagation, including Madin–Darby canine kidney (MDCK) cells. Avian viruses, introduced via use of embryonated eggs for virus isolation, were found to present the greatest risk, irrespective of the substrate used for influenza virus propagation. The use of MDCK cells to propagate vaccine virus from egg-isolated influenza virus strains does not introduce a new or greater adventitious virus risk, compared with egg-based vaccine production. Indeed, the adventitious virus risk is potentially reduced as fewer viruses are able to grow in MDCK cells.
has issue date	2008-06-19(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2008.03.076
bibo:pmid	18468737
has license	els-covid
sha1sum (hex)	91388764b01e051b00401e4efb12caca8b979484
schema:url	https://doi.org/10.1016/j.vaccine.2008.03.076
resource representing a document's title	A risk-assessment model to rate the occurrence and relevance of adventitious agents in the production of influenza vaccines
has PubMed Central identifier	PMC7115387
has PubMed identifier	18468737
schema:publication	Vaccine
resource representing a document's body	covid:91388764b01e051b00401e4efb12caca8b979484#body_text
is schema:about of	named entity 'RELEVANCE' named entity 'introduced' named entity 'introduce' named entity 'model' named entity 'account' named entity 'risk' named entity 'influenza' named entity 'production' named entity 'virus isolation' named entity 'eggs' named entity 'INFLUENZA VACCINES' named entity 'INTRODUCE' named entity 'IS A' named entity 'INTRODUCED' named entity 'INCLUDING' named entity 'GREATEST' named entity 'VACCINE' named entity 'ISOLATED' named entity 'VACCINE PRODUCTION' named entity 'INCIDENTAL' named entity 'EGGS' named entity 'CONVENTIONAL' named entity 'PRESENT' named entity 'CELLS' named entity '2C CELL' named entity 'RECENTLY' named entity 'METHODS' named entity 'DETERMINE' named entity 'CANINE' named entity 'BUT' named entity 'CELL CULTURE' named entity 'PRODUCTION' named entity 'ASSESSMENT' named entity 'KIDNEY' named entity 'POTENTIAL' named entity 'RISK OF' named entity 'INFLUENZA VACCINE' named entity 'VIRUS ISOLATION' named entity 'CULTURE' named entity 'RESISTANCE TO' named entity 'HAVE' named entity 'GROW' named entity 'MODEL' named entity 'NEW' named entity 'SUBSTRATE' named entity 'ASSESSMENT' named entity 'PROCESS' named entity 'PROCESSING' named entity 'ASSESS' named entity 'APPLIED' named entity 'FOUND' named entity 'SCENARIOS' named entity 'RATE' named entity 'MANUFACTURING' named entity 'VIRUSES' named entity 'RISK' named entity 'MODEL' named entity 'OCCURRENCE' named entity 'MANUFACTURE' named entity 'VIRAL PATHOGENS' named entity 'AVIAN' named entity 'REDUCED' named entity 'CELL' named entity 'STRAINS' named entity 'GREATER' named entity 'OF EACH' named entity 'STEPS' named entity 'ACCOUNT' named entity 'USING' named entity 'MDCK CELLS' named entity 'USE OF' named entity 'BASED' named entity 'COMPARED' named entity 'EGG' named entity 'PATHOGENS' named entity 'PROPAGATION' named entity 'RELEVANCE' named entity 'DOES NOT' named entity 'BASIC' named entity 'DERIVED' named entity 'DIFFERENT'

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