About: Surveillance of enteroviruses from paediatric patients attended at a tertiary hospital in Catalonia from 2014 to 2017

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About: Surveillance of enteroviruses from paediatric patients attended at a tertiary hospital in Catalonia from 2014 to 2017 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Surveillance of enteroviruses from paediatric patients attended at a tertiary hospital in Catalonia from 2014 to 2017
Creator	Rodrigo, Carlos Alcubilla, Pilar Andrés, Cristina Antón, Andrés Fuentes, Francisco Gimferrer, Laura Piñana, Maria Pumarola, Tomàs Rubio, Susana Esperalba, Juliana Codina, Maria Barnés, Meritxell Martín, Maria Vila, Jorgina
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Enterovirus (EV) infections are usually asymptomatic or mild, but symptomatic infections can evolve to severe complications. Outbreaks of EV-A71 and EV-D68 have been recently reported worldwide, sometimes related to severe clinical outcomes. OBJECTIVE: To describe EV genetic diversity and the clinical outcomes from paediatric patients attended at a tertiary university hospital in Barcelona (Catalonia, Spain) from 2014 to 2017. STUDY DESIGN: Specimens were collected from paediatric (<17 years old) cases with suspicion of respiratory tract infection or EV infection. EV laboratory-confirmation was performed by specific real-time multiplex RT-PCR assay. Partial viral VP1 protein was sequenced for genetic characterisation by phylogenetic analyses. RESULTS: A total of 376 (7%) from 5703 cases were EV laboratory-confirmed. Phylogenetic analyses of VP1 (210; 81%) sequences distinguished up to 27 different EV types distributed within EV-A (82; 40%), EV-B (90; 42%), EV-C (5; 2%), and EV-D (33; 15%), in addition to 50 (19%) rhinoviruses. The most predominant were EV-A71 (37; 45%) and EV-D68 (32; 99%). EV-A71 was highly related to neurological complications (25/39, 63%), of which 20/39 were rhombencephalitis, and most EV-D68 (28/32, 88%) were associated with lower respiratory tract infections (LRTI), and exceptionally one (3%) with acute flaccid paralysis. CONCLUSIONS: EV-A71 and EV-D68 were the most detected EV in respiratory specimens. EV-A71 was highly related to neurological disease and EV-D68 was often associated with LRTI. However, both potential relatedness to neurological diseases makes the monitoring of EV circulation obligatory.
has issue date	2018-11-30(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2018.11.004
bibo:pmid	30530096
has license	no-cc
sha1sum (hex)	915e3056104a5b9483451f8500bf9793966228cb
schema:url	https://doi.org/10.1016/j.jcv.2018.11.004
resource representing a document's title	Surveillance of enteroviruses from paediatric patients attended at a tertiary hospital in Catalonia from 2014 to 2017
has PubMed Central identifier	PMC7172671
has PubMed identifier	30530096
schema:publication	J Clin Virol
resource representing a document's body	covid:915e3056104a5b9483451f8500bf9793966228cb#body_text
is schema:about of	named entity 'infection' named entity 'highly' named entity '2017' named entity 'Catalonia' named entity 'complications' named entity 'addition' named entity 'respiratory' named entity 'worldwide' named entity 'attended' named entity 'tertiary hospital' named entity '287' named entity 'DETECTED' named entity 'USUALLY ASYMPTOMATIC' named entity 'EV-D68' named entity 'NEUROLOGICAL' named entity 'PROTEIN ' named entity 'real-time' named entity 'predominant' named entity 'Study design' named entity 'Outbreaks' named entity 'Barcelona' named entity 'cases' named entity 'acute flaccid paralysis' named entity 'infections' named entity 'asymptomatic' named entity 'EV-D68' named entity 'LRTI' named entity 'Enterovirus' named entity 'paediatric' named entity 'EV-D68' named entity 'EV-D68' named entity 'EV-A71' named entity 'Phylogenetic analyses' named entity 'protein' named entity 'acute flaccid paralysis' named entity 'tertiary university' named entity 'enteroviruses' named entity 'influenza viruses' named entity 'EV-C' named entity 'LRTI' named entity 'echovirus' named entity 'HFMD' named entity 'Vall d'Hebron University Hospital' named entity 'LRTI' named entity 'HFMD' named entity 'leukocyte count' named entity 'AFP' named entity 'EV-D68' named entity 'Europe' named entity 'clinical surveillance' named entity 'HFMD' named entity 'M.B.' named entity 'EV-D68' named entity 'LRTI' named entity 'CSF' named entity 'clinical findings' named entity 'myotatic' named entity 'EV-D68' named entity 'Genotyping' named entity 'aseptic meningitis' named entity 'EV-D68' named entity '20/25' named entity 'Gram stain' named entity 'multiplex PCR' named entity 'mechanical ventilation' named entity 'infection' named entity 'PCR' named entity 'EV-D68'

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