About: Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity

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About: Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
Creator	Margine, Irina Lang, Yifei Langereis, Martijn Bakkers, Mark De Groot Correspondence, Raoul De Groot, Raoul De Groot-Mijnes, Jolanda De Poot, Stefanie Feitsma, Louris Huizinga, Eric Hulswit, Ruben Van Kuppeveld, Frank Van Vliet, Arno
Source	Elsevier; Medline; PMC
abstract	Human beta1-coronavirus (β1CoV) OC43 emerged relatively recently through a single zoonotic introduction. Like related animal β1CoVs, OC43 uses 9-O-acetylated sialic acid as receptor determinant. β1CoV receptor binding is typically controlled by attachment/fusion spike protein S and receptor-binding/receptor-destroying hemagglutinin-esterase protein HE. We show that following OC43’s introduction into humans, HE-mediated receptor binding was selected against and ultimately lost through progressive accumulation of mutations in the HE lectin domain. Consequently, virion-associated receptor-destroying activity toward multivalent glycoconjugates was reduced and altered such that some clustered receptor populations are no longer cleaved. Loss of HE lectin function was also observed for another respiratory human coronavirus, HKU1. This thus appears to be an adaptation to the sialoglycome of the human respiratory tract and for replication in human airways. The findings suggest that the dynamics of virion-glycan interactions contribute to host tropism. Our observations are relevant also to other human respiratory viruses of zoonotic origin, particularly influenza A virus.
has issue date	2017-03-08(xsd:dateTime)
bibo:doi	10.1016/j.chom.2017.02.008
bibo:pmid	28279346
has license	no-cc
sha1sum (hex)	91f6f8f085ef08dc82f21acfd1fad30312153b27
schema:url	https://doi.org/10.1016/j.chom.2017.02.008
resource representing a document's title	Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
has PubMed Central identifier	PMC7104930
has PubMed identifier	28279346
schema:publication	Cell Host Microbe
resource representing a document's body	covid:91f6f8f085ef08dc82f21acfd1fad30312153b27#body_text
is schema:about of	named entity 'Graphical' named entity 'Adaptation' named entity 'INVOLVED' named entity 'INVOLVED' named entity 'SIALATE' named entity 'ABSTRACT' named entity 'SUMMARY' named entity 'TROPISM' named entity 'LOSS OF' named entity 'ADAPTION' named entity 'HUMANS' named entity 'LOST' named entity 'LECTIN' named entity 'MUTATIONS' named entity 'ACTIVITY' named entity 'ESTERASE' named entity 'LOSS OF' named entity 'DESTROYING' named entity 'PROGRESSIVE' named entity 'LECTIN ACTIVITY' named entity 'HUMANS' named entity 'ARTICLE' named entity 'HEMAGGLUTININ' named entity 'PROGRESSIVE' named entity 'BINDING SITE' named entity 'RECEPTOR BINDING' named entity 'CORONAVIRUSES' named entity 'ACCUMULATION' named entity 'HOST' named entity 'OC43' named entity 'BALANCE' named entity 'DESTRUCTION' named entity 'ADAPTATION' named entity 'BETACORONAVIRUS' named entity 'ACETYLESTERASE' named entity 'RECEPTOR' named entity 'FUNCTION' covid:arg/91f6f8f085ef08dc82f21acfd1fad30312153b27 named entity 'receptor' named entity 'destruction' named entity 'lost' named entity 'destroying' named entity 'receptor' named entity 'acetylesterase' named entity 'host tropism' named entity 'receptor binding' named entity 'receptor' named entity 'Betacoronavirus' named entity 'Hemagglutinin-Esterase' named entity 'BCoV' named entity 'PHEV' named entity 'transferase' named entity 'esterase' named entity 'OC43' named entity 'BCoV' named entity 'glycan' named entity 'OC43' named entity 'supernatant' named entity 'endemicity' named entity 'pNPA' named entity 'entire genomes' named entity 'protein' named entity 'receptor binding' named entity 'OC43' named entity 'alphacoronaviruses' named entity 'hemagglutination' named entity 'host species' named entity 'OC43' named entity 'genome sequences'

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