About: Metagenomics for neurological infections

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About: Metagenomics for neurological infections — expanding our imagination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Metagenomics for neurological infections — expanding our imagination
Creator	Wilson, Michael Ramachandran, Prashanth
Source	Medline; PMC
abstract	Over the past two decades, the diagnosis rate for patients with encephalitis has remained poor despite advances in pathogen-specific testing such as PCR and antigen assays. Metagenomic next-generation sequencing (mNGS) of RNA and DNA extracted from cerebrospinal fluid and brain tissue now offers another strategy for diagnosing neurological infections. Given that mNGS simultaneously assays for a wide range of infectious agents in an unbiased manner, it can identify pathogens that were not part of a neurologist’s initial differential diagnosis either because of the rarity of the infection, because the microorganism has not been previously associated with a clinical phenotype or because it is a newly discovered organism. This Review discusses the technical advantages and pitfalls of cerebrospinal fluid mNGS in the context of patients with neuroinflammatory syndromes, including encephalitis, meningitis and myelitis. We also speculate on how mNGS testing potentially fits into current diagnostic testing algorithms given data on mNGS test performance, cost and turnaround time. Finally, the Review highlights future directions for mNGS technology and other hypothesis-free testing methodologies that are in development.
has issue date	2020-07-13(xsd:dateTime)
bibo:doi	10.1038/s41582-020-0374-y
bibo:pmid	32661342
has license	no-cc
sha1sum (hex)	920438ec51b7c2d8f8198fe6c22b01df53900037
schema:url	https://doi.org/10.1038/s41582-020-0374-y
resource representing a document's title	Metagenomics for neurological infections — expanding our imagination
has PubMed Central identifier	PMC7356134
has PubMed identifier	32661342
schema:publication	Nat Rev Neurol
resource representing a document's body	covid:920438ec51b7c2d8f8198fe6c22b01df53900037#body_text
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