About: Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets

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About: Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets
Creator	Chen, Qi Gauger, Phillip Zhang, Jianqiang Madson, Darin Derscheid, Rachel Arruda, Paulo Brodie, Joseph Burrough, Eric Magstadt, Drew Stafne, Molly Thomas, Joseph Welch, Michael
source	Elsevier; Medline; PMC
abstract	Abstract Porcine deltacoronavirus (PDCoV) was first identified in Hong Kong in 2009–2010 and reported in United States swine for the first time in February 2014. However, diagnostic tools other than polymerase chain reaction for PDCoV detection were lacking and Koch׳s postulates had not been fulfilled to confirm the pathogenic potential of PDCoV. In the present study, PDCoV peptide-specific rabbit antisera were developed and used in immunofluorescence and immunohistochemistry assays to assist PDCoV diagnostics. The pathogenicity and pathogenesis of PDCoV was investigated following orogastric inoculation of 5-day-old piglets with a plaque-purified PDCoV cell culture isolate (3×104 TCID50 per pig). The PDCoV-inoculated piglets developed mild to moderate diarrhea, shed increasing amount of virus in rectal swabs from 2 to 7 days post inoculation, and developed macroscopic and microscopic lesions in small intestines with viral antigen confirmed by immunohistochemistry staining. This study experimentally confirmed PDCoV pathogenicity and characterized PDCoV pathogenesis in neonatal piglets.
has issue date	2015-08-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2015.03.024
bibo:pmid	25817405
has license	els-covid
sha1sum (hex)	92132bdeacb28b713ecf82239a572731cc3b660b
schema:url	https://doi.org/10.1016/j.virol.2015.03.024
resource representing a document's title	Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets
has PubMed Central identifier	PMC7111688
has PubMed identifier	25817405
schema:publication	Virology
resource representing a document's body	covid:92132bdeacb28b713ecf82239a572731cc3b660b#body_text
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