About: Functional SARS-CoV-2-specific immune memory persists after mild COVID-19

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About: Functional SARS-CoV-2-specific immune memory persists after mild COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
Creator	Gale, Michael Chen, Yu Netland, Jason Campbell, J Hemann, Emily King, Neil Carter, Lauren Eggenberger, Julie Fahning, Mitchell Fiala, Brooke Hamerman, Jessica Morawski, Peter Pepper, Marion Pruner, Kurt Rathe, Jennifer Rawlings, David Rodda, Lauren Shehata, Laila Stokes, Caleb Takehara, Kennidy Thouvenel, Chris Wrenn, Samuel
Source	Medline; PMC
abstract	The recently emerged SARS-CoV-2 virus is currently causing a global pandemic and cases continue to rise. The majority of infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that might contribute to herd immunity. Thus, we performed a longitudinal assessment of individuals recovered from mildly symptomatic COVID-19 to determine if they develop and sustain immunological memory against the virus. We found that recovered individuals developed SARS-CoV-2-specific IgG antibody and neutralizing plasma, as well as virus-specific memory B and T cells that not only persisted, but in some cases increased numerically over three months following symptom onset. Furthermore, the SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral immunity: memory T cells secreted IFN-γ and expanded upon antigen re-encounter, while memory B cells expressed receptors capable of neutralizing virus when expressed as antibodies. These findings demonstrate that mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks associated with antiviral protective immunity.
has issue date	2020-08-13(xsd:dateTime)
bibo:doi	10.21203/rs.3.rs-57112/v1
bibo:pmid	32818218
has license	cc-by
sha1sum (hex)	925e274f16bf77c12a32883cff0844582e9841c4
schema:url	https://doi.org/10.21203/rs.3.rs-57112/v1
resource representing a document's title	Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
has PubMed Central identifier	PMC7430600
has PubMed identifier	32818218
schema:publication	Res Sq
resource representing a document's body	covid:925e274f16bf77c12a32883cff0844582e9841c4#body_text
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