About: Protective effects of the Francisella tularensis ΔpdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Protective effects of the Francisella tularensis ΔpdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Protective effects of the Francisella tularensis ΔpdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques
Creator	Morikawa, Shigeru Nagata, Noriyo Ami, Yasushi Iwata-Yoshikawa, Naoko Uda, Akihiko Park, Eun-Sil Azaki, Mika Hotta, Akitoyo Tian, Deyu Yamada, Akio Hirayama, Kazuhiro Koyama, Yuki Miura, Kozue
source	PMC
abstract	Tularemia is a severe infectious zoonotic disease caused by Francisella tularensis. Although F. tularensis is considered to be a potential biological weapon due to its high infectivity and mortality rate, no vaccine has been currently licensed. Recently, we reported that F. tularensis SCHU P9 derived ΔpdpC strain lacking the pathogenicity determinant protein C gene conferred stable and good protection in a mouse lethal model. In this study, the protective effect of ΔpdpC was evaluated using a monkey lethal model. Two cynomolgus macaques (Macaca fascicularis) intratracheally challenged with the virulent strain SCHU P9 were euthanized on 7 and 11 days post-challenge after the development of severe clinical signs. The bacterial replication in alveolar macrophages and type II epithelial cells in the lungs would cause severe pneumonia accompanied by necrosis. Conversely, two animals subcutaneously immunized with ΔpdpC survived 3 weeks after SCHU P9 challenge. Though one of the two animals developed mild symptoms of tularemia, bacterial replication was limited in the respiratory organs, which may be due to a high level of humoral and cellular immune responses against F. tularensis. These results suggest that the ΔpdpC mutant would be a safe and promising candidate as a live attenuated tularemia vaccine.
has issue date	2019-06-24(xsd:dateTime)
bibo:doi	10.1038/s41598-019-45412-8
bibo:pmid	31235714
has license	cc-by
sha1sum (hex)	92663b93c60bb3ddfa270dc105dbf28ec853eae5
schema:url	https://doi.org/10.1038/s41598-019-45412-8
resource representing a document's title	Protective effects of the Francisella tularensis ΔpdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques
has PubMed Central identifier	PMC6591246
has PubMed identifier	31235714
schema:publication	Sci Rep
resource representing a document's body	covid:92663b93c60bb3ddfa270dc105dbf28ec853eae5#body_text
is schema:about of	named entity 'type II' named entity 'necrosis' named entity 'strain' named entity 'macaques' named entity 'These' named entity 'animals' named entity 'derived' named entity 'vaccine' named entity 'clinical signs' named entity 'cynomolgus' named entity 'lethal' named entity 'F. tularensis' named entity 'model' named entity 'tularemia' named entity 'alveolar macrophages' named entity 'biological weapon' named entity 'F. tularensis' named entity 'clinical signs' named entity 'lungs' named entity 'Francisella tularensis' named entity 'virulent strain' named entity 'live attenuated' named entity 'infectivity' named entity 'accompanied' named entity 'potential' named entity 'vaccination' named entity 'gene knockout' named entity 'ACE2' named entity 'subcutaneously' named entity 'group II intron' named entity 'LPS' named entity 'immunohistochemical staining' named entity 'optical density' named entity 'nature.com' named entity 'vaccination' named entity 'serum' named entity 'lungs' named entity 'macaques' named entity 'cellular immune responses' named entity 'tularemia' named entity 'F. tularensis' named entity 'antigen' named entity 'tracheas' named entity 'IgG' named entity 'Listeria monocytogenes' named entity 'immune responses' named entity 'ACE2' named entity 'thrice' named entity 'goat' named entity 'non-human primate' named entity 'renin' named entity 'vaccine testing' named entity 'LPS' named entity 'virulent strain' named entity 'F. tularensis' named entity 'signs of infection' named entity 'goat' named entity 'ELISpot' named entity 'Group 3' named entity 'Group 3' named entity 'Immunohistochemical' named entity 'clinical signs' named entity 'inoculation' named entity 'virulent strain' named entity 'bacterial culture' named entity 'subspecies' named entity 'serum samples' named entity 'F. tularensis' named entity 'tularemia'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software