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About:
Experimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures
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wasabi.inria.fr
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Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Experimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures
Creator
Matthijnssens, Jelle
Conceição-Neto, Nádia
Van Ranst, Marc
Nauwynck, Hans
Zeller, Mark
Theuns, Sebastiaan
Desmarets, Lowiese
Acar, Delphine
Olyslaegers, Dominique
Roukaerts, Inge
Vermeulen, Ben
Source
Medline; PMC
abstract
Feline infectious peritonitis (FIP) results from mutations in the viral genome during a common feline enteric coronavirus (FECV) infection. Since many virological and immunological data on FECV infections are lacking, the present study investigated these missing links during experimental infection of three SPF cats with FECV strain UCD. Two cats showed mild clinical signs, faecal shedding of infectious virus from 4 dpi, a cell-associated viraemia at inconsistent time points from 5 dpi, a highly neutralising antibody response from 9 dpi, and no major abnormalities in leukocyte numbers. Faecal shedding lasted for 28–56 days, but virus shed during this stage was less infectious in enterocyte cultures and affected by mutations. Remarkably, in the other cat neither clinical signs nor acute shedding were seen, but virus was detected in blood cells from 3 dpi, and shedding of non-enterotropic, mutated viruses suddenly occurred from 14 dpi onwards. Neutralising antibodies arose from 21 dpi. Leukocyte numbers were not different compared to the other cats, except for the CD8(+) regulatory T cells. These data indicate that FECV can infect immune cells even in the absence of intestinal replication and raise the hypothesis that the gradual adaptation to these cells can allow non-enterotropic mutants to arise.
has issue date
2016-01-29
(
xsd:dateTime
)
bibo:doi
10.1038/srep20022
bibo:pmid
26822958
has license
cc-by
sha1sum (hex)
926c0d5330eefdb58452c054c8387da92e9d0590
schema:url
https://doi.org/10.1038/srep20022
resource representing a document's title
Experimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures
has PubMed Central identifier
PMC4731813
has PubMed identifier
26822958
schema:publication
Sci Rep
resource representing a document's body
covid:926c0d5330eefdb58452c054c8387da92e9d0590#body_text
is
schema:about
of
named entity 'A CELL'
named entity 'DETECTED'
named entity 'AFFECTED'
named entity 'ACUTE'
named entity 'EXPERIMENTAL INFECTION'
named entity 'ANTIBODY RESPONSE'
named entity 'BUT'
named entity 'DPI'
named entity 'HYPOTHESIS'
named entity 'DATA'
named entity 'SEEN'
named entity 'FAECAL'
named entity 'NEUTRALISING ANTIBODIES'
named entity 'DIFFERENT'
named entity 'STUDY'
named entity 'VIRUS'
named entity 'SPF'
named entity 'NON-'
named entity 'DAYS'
named entity 'NEUTRALISING ANTIBODY'
named entity 'FECV'
named entity 'CELLS'
named entity 'CLINICAL SIGNS'
named entity 'MUTANTS'
named entity 'INFECTIVITY'
named entity 'detected'
named entity 'infect'
named entity 'mutants'
named entity 'infectivity'
named entity 'ABERRANT'
named entity 'EXPERIMENTAL'
named entity 'REGULATORY T CELLS'
named entity 'HIGHLY'
named entity 'VIRAEMIA'
named entity 'SHEDDING'
named entity 'VIRUSES'
named entity 'ADAPTATION'
named entity 'LINKS'
named entity 'INVESTIGATED'
named entity 'CATS'
named entity 'STRAIN'
named entity 'COMPARED'
named entity 'NEITHER'
named entity 'IMMUNE CELLS'
named entity 'INFECTIOUS'
named entity 'GRADUAL'
named entity 'FELINE ENTERIC CORONAVIRUS'
named entity 'CULTURES'
named entity 'PATTERN'
named entity 'OPEN'
named entity 'CORONAVIRUS INFECTION'
named entity 'IMPAIRED'
named entity 'IN BLOOD'
named entity 'MUTANTS'
named entity 'PRESENT'
named entity 'ABNORMALITIES'
named entity 'ASSOCIATED'
named entity 'INTESTINAL'
named entity 'MISSING'
named entity 'REPLICATION'
named entity 'MUTATIONS'
named entity 'TIME'
named entity 'ENTEROCYTE'
named entity 'CD8'
named entity 'LEUKOCYTE'
named entity 'THESE'
named entity 'BLOOD CELLS'
named entity 'ALLOW'
named entity 'MAJOR'
named entity 'INFECTION'
named entity 'SHEDDING'
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