About: BACKGROUND: Considerable evidence suggests that smell dysfunction is common in Coronavirus Disease 2019 (COVID‐19). Unfortunately, extant data on prevalence and reversibility over time are highly variable, coming mainly from self‐report surveys prone to multiple biases. Thus, validated psychophysical olfactory testing is sorely needed to establish such parameters. METHODS: One hundred SARS‐CoV‐2 positive cases were administered the 40‐item University of Pennsylvania Smell Identification Test (UPSIT) in the hospital near the end of the acute phase of the disease. Eighty‐two were retested 1 or 4 weeks later at home. The data were analyzed using analysis of variance and mixed‐effect regression models. RESULTS: Initial UPSIT scores were indicative of severe microsmia, with 96% exhibiting measurable dysfunction; 18% were anosmic. The scores improved upon retest [initial and retest means (95%CIs) = 21.97 (20.84,23.09) & 31.13 (30.16,32.10; p<0.0001)]; no patient remained anosmic. After five weeks from COVID‐19 symptom onset, the test scores of 63% of the retested patients were normal. However, the mean UPSIT score at that time continued to remain below that of age‐ and sex‐matched healthy controls (p<0.001). Such scores were related to time since symptom onset, sex, and age. CONCLUSION: Smell loss was extremely common in the acute phase of a cohort of 100 COVID‐19 patients when objectively measured. About one‐third of cases continued to exhibit dysfunction after five post‐symptom onset weeks. These findings have direct implications for the use of olfactory testing in identifying SARS‐CoV‐2 virus carriers and for counseling such patients in regards to their smell dysfunction and its reversibility. This article is protected by copyright. All rights reserved   Goto Sponge  NotDistinct  Permalink

An Entity of Type : fabio:Abstract, within Data Space : wasabi.inria.fr associated with source document(s)

AttributesValues
type
value
  • BACKGROUND: Considerable evidence suggests that smell dysfunction is common in Coronavirus Disease 2019 (COVID‐19). Unfortunately, extant data on prevalence and reversibility over time are highly variable, coming mainly from self‐report surveys prone to multiple biases. Thus, validated psychophysical olfactory testing is sorely needed to establish such parameters. METHODS: One hundred SARS‐CoV‐2 positive cases were administered the 40‐item University of Pennsylvania Smell Identification Test (UPSIT) in the hospital near the end of the acute phase of the disease. Eighty‐two were retested 1 or 4 weeks later at home. The data were analyzed using analysis of variance and mixed‐effect regression models. RESULTS: Initial UPSIT scores were indicative of severe microsmia, with 96% exhibiting measurable dysfunction; 18% were anosmic. The scores improved upon retest [initial and retest means (95%CIs) = 21.97 (20.84,23.09) & 31.13 (30.16,32.10; p<0.0001)]; no patient remained anosmic. After five weeks from COVID‐19 symptom onset, the test scores of 63% of the retested patients were normal. However, the mean UPSIT score at that time continued to remain below that of age‐ and sex‐matched healthy controls (p<0.001). Such scores were related to time since symptom onset, sex, and age. CONCLUSION: Smell loss was extremely common in the acute phase of a cohort of 100 COVID‐19 patients when objectively measured. About one‐third of cases continued to exhibit dysfunction after five post‐symptom onset weeks. These findings have direct implications for the use of olfactory testing in identifying SARS‐CoV‐2 virus carriers and for counseling such patients in regards to their smell dysfunction and its reversibility. This article is protected by copyright. All rights reserved
Subject
  • Zoonoses
  • Neuroscience
  • Viral respiratory tract infections
  • COVID-19
  • Intellectual property law
  • Occupational safety and health
  • Survey methodology
  • Branches of psychology
  • Public domain
  • Cognitive psychology
  • Copyright law
  • Psychophysics
  • Copyright law legal terminology
  • Stock media
part of
is abstract of
is hasSource of
Faceted Search & Find service v1.13.91 as of Mar 24 2020


Alternative Linked Data Documents: Sponger | ODE     Content Formats:       RDF       ODATA       Microdata      About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software