About: Integrated Blood Barcode Chips

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Integrated Blood Barcode Chips
Creator	Ahmad, Habib Fan, Rong Gould, Juliane Hood, Leroy Liu, Chao-Chao Qin, Lidong Srivastava, Alok Vermesh, Ophir Heath, James Kwong, Gabriel Yen, Brian
Source	Medline; PMC
abstract	Blood comprises the largest version of the human proteome1. Changes of plasma protein profiles can reflect physiological or pathological conditions associated with many human diseases, making blood the most important fluid for clinical diagnostics2-4. Nevertheless, only a handful of plasma proteins are utilized in routine clinical tests. This is due to a host of reasons, including the intrinsic complexity of the plasma proteome1, the heterogeneity of human diseases and the fast kinetics associated with protein degradation in sampled blood5. Simple technologies that can sensitively sample large numbers of proteins over broad concentration ranges, from small amounts of blood, and within minutes of sample collection, would assist in solving these problems. Herein, we report on an integrated microfluidic system, called the Integrated Blood Barcode Chip (IBBC). It enables on-chip blood separation and the rapid measurement of a panel of plasma proteins from small quantities of blood samples including a fingerprick of whole blood. This platform holds potential for inexpensive, non-invasive, and informative clinical diagnoses, particularly, for point-of-care.
has issue date	2008-11-16(xsd:dateTime)
bibo:doi	10.1038/nbt.1507
bibo:pmid	19029914
has license	no-cc
sha1sum (hex)	92a874a4d2371061665a018eee85abf9e857ebc2
schema:url	https://doi.org/10.1038/nbt.1507
resource representing a document's title	Integrated Blood Barcode Chips
has PubMed Central identifier	PMC2775523
has PubMed identifier	19029914
schema:publication	Nat Biotechnol
resource representing a document's body	covid:92a874a4d2371061665a018eee85abf9e857ebc2#body_text
is schema:about of	named entity 'plasma' named entity 'problems' named entity 'microfluidic' named entity 'informative' named entity 'plasma protein' named entity 'Barcode' named entity 'CHIPS' named entity 'INTEGRATED' named entity 'LARGEST' named entity 'BLOOD' named entity 'WHOLE BLOOD' named entity 'NUMBERS' named entity 'POINT-OF-CARE' named entity 'FAST' named entity 'PATHOLOGICAL' named entity 'MICROFLUIDIC' named entity 'FLUID' named entity 'CHIP' named entity 'IMPORTANT' named entity 'CONDITIONS' named entity 'INTEGRATED' named entity 'BARCODE' named entity 'CONCENTRATION' named entity 'DIAGNOSES' named entity 'MEASUREMENT' named entity 'ASSIST' named entity 'BARCODE' named entity 'PROBLEMS' named entity 'QUANTITIES' named entity 'BROAD' named entity 'HETEROGENEITY' named entity 'KINETICS' named entity 'NON-INVASIVE' named entity 'BLOOD SAMPLES' named entity 'COMPLEXITY' named entity 'SEPARATION' named entity 'TESTS' named entity 'SMALL' named entity 'PLASMA PROTEINS' named entity 'INFORMATIVE' named entity 'DUE TO' named entity 'ROUTINE' named entity 'SAMPLE' named entity 'BLOOD' named entity 'TECHNOLOGIES' named entity 'ENABLES' named entity 'INCLUDING' named entity 'PROTEIN DEGRADATION' named entity 'INTRINSIC' named entity 'SIMPLE' named entity 'HUMAN' named entity 'THESE' named entity 'REFLECT' named entity 'REASONS' named entity 'CHANGES' named entity 'PHYSIOLOGICAL' named entity 'HUMAN DISEASES' named entity 'PLASMA PROTEIN' named entity 'LARGE' named entity 'PLASMA' named entity 'CLINICAL' named entity 'POTENTIAL' named entity 'PROTEINS' named entity 'SAMPLED' named entity 'AMOUNTS' named entity 'ASSOCIATED WITH' named entity 'SAMPLE COLLECTION' named entity 'REPORT' named entity 'PANEL' named entity 'PROTEIN ' named entity 'PLATFORM'

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