About: Monoclonal antiprothrombinase (3D4.3) prevents mortality from murine hepatitis virus (MHV-3) infection

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About: Monoclonal antiprothrombinase (3D4.3) prevents mortality from murine hepatitis virus (MHV-3) infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Monoclonal antiprothrombinase (3D4.3) prevents mortality from murine hepatitis virus (MHV-3) infection
Creator	Li, C Chung, S Fung, L Cole, C Crow, A Leibowitz, S Levy, G Myers-Mason, N Ottaway, Phillips, M
topic	covid:9363422a0f9b40cd6bb8f6c7fbbcaadf146f20a6#this
Source	PMC
abstract	The induction of monocyte/macrophage procoagulant activity (PCA) has been implicated in the pathogenesis of murine hepatitis virus strain 3 (MHV-3) infection and disease. Previously, we have shown that induction of PCA by MHV-3 correlated with resistance/susceptibility to infection in different mouse strains. In this study, all BALB/cJ mice that were infected with 10(3) plaque-forming units of MHV-3 developed severe liver disease and died within 96-120 h. Examination of the livers of these animals showed marked hepatic necrosis, deposition of fibrin, and cellular expression of PCA by direct immunofluorescence staining in areas of necrosis as well as in hepatic sinusoids. Splenic mononuclear cells recovered from these mice expressed high concentrations of PCA with time after infection. Infusion into mice of a high-titered monoclonal antibody that neutralized PCA (3D4.3) attenuated the development of hepatic necrosis and enhanced survival in a dose- dependent manner. All of the animals receiving 100 micrograms, and 44% and 22% of the animals that received 50 and 25 micrograms per day, respectively, survived for 10 d and made a full recovery. Administration of the antibody resulted in a dose-dependent reduction in fibrin deposition, PCA expression as detected by direct immunofluorescence staining and by a functional assay. In animals treated with high concentrations of antibody, titers of antibody to PCA fell from 87 +/- 15 micrograms/ml to 100 +/- 7 ng/ml during the active phase of the disease, consistent with sequestration due to binding of the immunoglobulin to cells expressing PCA. Surviving animals, when rechallenged with MHV-3, had a 40% mortality, consistent with the known rates of metabolism of immunoglobulin. This further suggested that protection was by a passive mechanism. The results reported here demonstrate that a neutralizing antibody to PCA protects animals from fulminant hepatitis and death associated with MHV-3 infection, and supports the notion that PCA is a potent inflammatory mediator that plays a pivotal role in the pathogenesis of liver injury resulting from MHV-3 infection.
has issue date	1992-09-01(xsd:dateTime)
bibo:pmid	1324969
has license	cc-by-nc-sa
sha1sum (hex)	9363422a0f9b40cd6bb8f6c7fbbcaadf146f20a6
resource representing a document's title	Monoclonal antiprothrombinase (3D4.3) prevents mortality from murine hepatitis virus (MHV-3) infection
has PubMed Central identifier	PMC2119354
has PubMed identifier	1324969
schema:publication	J Exp Med
resource representing a document's body	covid:9363422a0f9b40cd6bb8f6c7fbbcaadf146f20a6#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/9363422a0f9b40cd6bb8f6c7fbbcaadf146f20a6
is schema:about of	named entity 'reduction' named entity 'MHV' named entity 'recovered' named entity 'consistent' named entity 'animals' named entity 'MORTALITY' named entity 'ANTIPROTHROMBINASE' covid:arg/9363422a0f9b40cd6bb8f6c7fbbcaadf146f20a6 named entity 'PER DAY' named entity 'REDUCTION' named entity 'ADMINISTRATION' named entity 'HAVE' named entity 'DIED' named entity 'MURINE HEPATITIS VIRUS STRAIN 3' named entity '40%' named entity 'ROLE' named entity 'ANTIBODY' named entity 'PLAQUE-FORMING UNITS' named entity 'MORTALITY' named entity 'DETECTED' named entity 'PROCOAGULANT ACTIVITY' named entity 'ATTENUATED' named entity 'OF LIVER INJURY' named entity 'INFUSION' named entity 'FULL RECOVERY' named entity 'MICE' named entity 'MECHANISM' named entity 'MONONUCLEAR CELLS' named entity 'PCA' named entity '103' named entity 'MONOCYTE' named entity 'PATHOGENESIS' named entity '100' named entity 'NEUTRALIZING ANTIBODY' named entity 'RECEIVING' named entity 'SEQUESTRATION' named entity 'STUDY' named entity 'RECOVERED' named entity 'INDUCTION' named entity 'IS A' named entity '23G' named entity 'DUE TO' named entity 'FULMINANT HEPATITIS' named entity 'CORRELATED' named entity 'LIVER DISEASE' named entity 'PREVENTS' named entity 'MURINE HEPATITIS VIRUS' named entity 'MONOCLONAL' named entity 'PROTECTION' named entity 'EXAMINATION' named entity 'IMMUNOFLUORESCENCE STAINING' named entity 'ACTIVE' named entity 'INFECTION' named entity 'DEATH ASSOCIATED' named entity 'KNOWN' named entity 'RESULTING FROM' named entity 'MHV' named entity 'MONOCLONAL ANTIBODY' named entity 'BINDING' named entity 'WITH TIME' named entity 'RESULTS' named entity 'BALB' named entity 'SURVIVAL' named entity 'ENHANCED' named entity 'HEPATIC SINUSOIDS' named entity 'PASSIVE' named entity 'SPLENIC' named entity 'SEVERE' named entity 'RATES' named entity '120' named entity 'INFECTION' named entity 'HERE'

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