About: Anti-cariogenic Characteristics of Rubusoside

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About: Anti-cariogenic Characteristics of Rubusoside Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anti-cariogenic Characteristics of Rubusoside
Creator	Kim, Doman Kim, Jeesoo Kim, Seong-Bo Jin, Juhui Jung, You-Jin Lee, Gang-Hee Mok, Kyoon Nguyen, Hanh Pal, Kunal Qureshi, Dilshad Septiana, Iis Son, Gyu-Min Thanh, Thi Yang, Soo-Yeon
source	PMC
abstract	Streptococcus mutans plays an important role in the development of dental caries in humans by synthesizing adhesive insoluble glucans from sucrose by mutansucrase activity. To explore the anti-cariogenic characteristics of rubusoside (Ru), a natural sweetener component in Rubus suavissimus S. Lee (Rosaceae), we investigated the inhibitory effect of Ru against the activity of mutansucrase and the growth of Streptococcus mutans. Ru (50 mM) showed 97% inhibitory activity against 0.1 U/mL mutansucrase of S. mutans with 500 mM sucrose. It showed competitive inhibition with a K(i) value of 1.1 ± 0.2 mM and IC(50) of 2.3 mM. Its inhibition activity was due to hydrophobic and hydrogen bonding interactions based on molecular docking analysis. Ru inhibited the growth of S. mutans as a bacteriostatic agent, with MIC and MBC values of 6 mM and 8 mM, respectively. In addition, Ru showed synergistic anti-bacterial activity when it was combined with curcumin. Therefore, Ru is a natural anti-cariogenic agent with anti-mutansucrase activity and antimicrobial activity against S. mutans. ELECTRONIC SUPPLEMENTARY MATERIAL (ESM): The online version of this article (doi: 10.1007/s12257-018-0408-0) contains supplementary material, which is available to authorized users.
has issue date	2019-05-18(xsd:dateTime)
bibo:doi	10.1007/s12257-018-0408-0
has license	no-cc
sha1sum (hex)	9487c68a62c5a68d04485adceab1422145df7efc
schema:url	https://doi.org/10.1007/s12257-018-0408-0
resource representing a document's title	Anti-cariogenic Characteristics of Rubusoside
has PubMed Central identifier	PMC7090897
schema:publication	Biotechnol Bioprocess Eng
resource representing a document's body	covid:9487c68a62c5a68d04485adceab1422145df7efc#body_text
is schema:about of	named entity 'synergistic' named entity 'activity' named entity 'addition' named entity 'sweetener' named entity 'activity' named entity 'CHARACTERISTICS' named entity 'BASED' named entity 'AGENT' named entity 'SUCROSE' named entity 'ANTIMICROBIAL ACTIVITY' named entity 'ROLE' named entity 'SYNERGISTIC' named entity 'ANTI-BACTERIAL' named entity 'COMPETITIVE INHIBITION' named entity 'RUBUSOSIDE' named entity 'PLAYS' named entity 'DEVELOPMENT' named entity 'RUBUS' named entity 'VALUES' named entity 'HYDROPHOBIC' named entity 'ACTIVITY' named entity 'INHIBITION' named entity '3 MM' covid:arg/9487c68a62c5a68d04485adceab1422145df7efc named entity 'ITS' named entity 'RUBUSOSIDE' named entity 'GROWTH' named entity 'INVESTIGATED' named entity '0.2' named entity 'CARIOGENIC' named entity 'VALUE' named entity 'INHIBITORY ACTIVITY' named entity 'INHIBITORY EFFECT' named entity 'CARIOGENIC' named entity 'BACTERIAL ACTIVITY' named entity 'COMPONENT' named entity 'STREPTOCOCCUS MUTANS' named entity '0.1' named entity '2 MM' named entity 'CURCUMIN' named entity 'NATURAL' named entity 'IS A' named entity 'ANALYSIS' named entity 'ADDITION' named entity 'MOLECULAR DOCKING' named entity 'DUE TO' named entity 'GLUCANS' named entity '1.1' named entity 'MIC' named entity 'LEE' named entity 'COMBINED' named entity 'INSOLUBLE' named entity 'MBC' named entity 'NATURAL SWEETENER' named entity 'CHARACTERISTICS' named entity 'ADHESIVE' named entity 'IMPORTANT' named entity 'INTERACTIONS' named entity 'HYDROGEN BONDING' named entity 'DENTAL CARIES' named entity '6 MM' named entity '500' named entity 'HUMANS' named entity 'INHIBITED' named entity 'plays' named entity 'inhibited' named entity 'antimicrobial' named entity 'hydrogen bonding' named entity 'agent' named entity 'investigated'

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