About: Design, Synthesis and Antiviral Efficacy of a Series of Potent Chloropyridyl Ester-derived SARS-CoV 3CLpro Inhibitors

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Design, Synthesis and Antiviral Efficacy of a Series of Potent Chloropyridyl Ester-derived SARS-CoV 3CLpro Inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Design, Synthesis and Antiviral Efficacy of a Series of Potent Chloropyridyl Ester-derived SARS-CoV 3CLpro Inhibitors
Creator	Mesecar, Andrew Coughlin, Melissa Sleeman, Katrina Grum-Tokars, Valerie Johnson, Michael Gong, Gangli Baker, Susan Ghosh, Arun Mulhearn, Debbie Prabhakar, Bellur
source	Elsevier; Medline; PMC
abstract	Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. Inhibitor 10 with a 5-chloropyridinyl ester at position 4 of the indole ring is the most potent inhibitor with a SARS 3Clpro IC(50) value of 30 nM and antiviral EC(50) value of 6.9 μM. Molecular Docking studies have provided possible binding modes of these inhibitors. [Image: see text]
has issue date	2008-10-01(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2008.08.082
bibo:pmid	18796354
has license	bronze-oa
sha1sum (hex)	948b45d3eca1a43e5358920f853e10106cc7cf57
schema:url	https://doi.org/10.1016/j.bmcl.2008.08.082
resource representing a document's title	Design, Synthesis and Antiviral Efficacy of a Series of Potent Chloropyridyl Ester-derived SARS-CoV 3CLpro Inhibitors
has PubMed Central identifier	PMC2745596
has PubMed identifier	18796354
schema:publication	Bioorganic & Medicinal Chemistry Letters
resource representing a document's body	covid:948b45d3eca1a43e5358920f853e10106cc7cf57#body_text
is schema:about of	named entity 'severe' named entity 'biological' named entity 'antiviral' named entity 'SARS-CoV' named entity 'EFFICACY' named entity 'ESTER' named entity 'BINDING' named entity 'SARS-COV' named entity 'ANTIVIRAL' named entity 'MOLECULAR DOCKING' named entity 'SYNTHESIS' named entity 'CARBOXYLATE' named entity 'VALUE' named entity 'RING' named entity 'BIOLOGICAL EVALUATION' named entity 'STUDIES' named entity 'CHLOROPYRIDINE' named entity 'DERIVED' named entity 'ANTIVIRAL' named entity 'SERIES' covid:arg/948b45d3eca1a43e5358920f853e10106cc7cf57 named entity 'DESIGN' named entity 'DESIGN' named entity '3CLPRO INHIBITORS' named entity 'SARS-COV' named entity 'SYNTHESIS' named entity 'THESE' named entity 'DESCRIBED' named entity 'POSITION' named entity 'INHIBITOR' named entity 'SERIES' named entity 'ESTER' named entity 'HAVE' named entity 'POSSIBLE' named entity 'INDOLE' named entity '6.9' named entity 'CRITICAL' named entity 'PROTEASE INHIBITORS' named entity 'POTENCY' named entity 'DERIVED' named entity 'PROVIDED' named entity 'FUNCTIONALITY' named entity 'CHYMOTRYPSIN-LIKE PROTEASE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'CORONAVIRUS' named entity 'inhibitors' named entity 'Inhibitor' named entity 'Design' named entity 'potent' named entity 'potent' named entity 'Molecular docking' named entity 'carboxylate' named entity 'ester' named entity 'protease inhibitors' named entity 'SARS-CoV' named entity 'peptidomimetic' named entity 'chymotrypsin-like' named entity 'SARS-CoV' named entity 'indole' named entity 'cysteine' named entity 'protease' named entity 'genome' named entity 'replicase' named entity 'assay' named entity 'SARS' named entity 'antiviral activity' named entity 'enzyme' named entity 'active site' named entity 'Covalent modification' named entity 'SARS-CoV' named entity 'ligand' named entity '3CLpro'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software