About: Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis

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About: Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis
Creator	Alberti-Navarro, Aldo Alcalá, Yazmin Froylan, Canto Jesus, Gracia-Mora Sumano-Lopez, Ibarra-Velarde
Source	Medline; PMC
abstract	Using the film in situ zymography (FIZ) technique, it has been demonstrated that N-[N-(l-3-trans-carboxyoxirane-2-carbonyl)-l-leucyl]-agmatine (E-64) inhibits Fasciola hepatica proteolytic activity in vivo. The aim of this study was to establish the dose-response relationship of the inhibition of proteolysis as assessed by FIZ with E-64 at different dosages in a murine model of fasciolosis. Maximum effective inhibition of proteolysis was achieved at 50 mg/kg/day (87%). Mice treated with this dose survived for a mean of 10.92 days more than untreated controls, and their ova counts and egg viability were significantly (P<0.05) lower than this latter group. These results indicate that intraperitoneal administration of E-64 not only inhibited liver proteolytic activity in a dose-dependent manner but also produced anti-fecundity and anti-embryonation effects, delaying the progression of fasciolosis. Yet, residual proteolysis may suggest that other E-64-non-sensitive enzymes are involved, or that E-64-enzyme chemical interactions are only capable of a partial agonistic-like effect.
has issue date	2006-01-06(xsd:dateTime)
bibo:doi	10.1007/s00436-005-0046-2
bibo:pmid	16397759
has license	no-cc
sha1sum (hex)	9548160f9662e7c5a6a2422d2e2dc90e4ecc6884
schema:url	https://doi.org/10.1007/s00436-005-0046-2
resource representing a document's title	Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis
has PubMed Central identifier	PMC7087701
has PubMed identifier	16397759
schema:publication	Parasitol Res
resource representing a document's body	covid:9548160f9662e7c5a6a2422d2e2dc90e4ecc6884#body_text
is schema:about of	named entity 'demonstrated' named entity 'interactions' named entity 'survived' named entity 'manner' named entity 'effects' named entity 'treated' named entity 'dose-dependent' named entity 'RESPONSE INHIBITION' named entity 'PROTEOLYTIC ACTIVITY' named entity 'NON-' named entity 'FASCIOLOSIS' named entity 'EFFECTS' named entity 'MICE' named entity 'ENZYMES' named entity 'AGMATINE' named entity 'PROTEOLYSIS' named entity 'INTERACTIONS' named entity 'MURINE' named entity 'UNTREATED' named entity 'PROGRESSION' named entity 'OVA' named entity 'COUNTS' named entity 'BUT' named entity 'INTRAPERITONEAL ADMINISTRATION' named entity 'DOSE-DEPENDENT' named entity 'DAYS' named entity 'RESULTS' named entity 'EGG' named entity 'IN VIVO' named entity 'SUGGEST' named entity 'DOSAGES' named entity 'E-64' named entity 'L-LEUCYL' named entity 'CAPABLE' named entity 'ENZYME' named entity 'ESTABLISH' named entity 'TECHNIQUE' named entity 'THESE' named entity '28P' named entity 'FILM' named entity 'VIABILITY' named entity 'MODEL OF' named entity 'MORE THAN' named entity 'DIFFERENT' named entity 'EFFECTIVE' named entity 'SENSITIVE' named entity 'IN SITU' named entity 'MG%' named entity 'THEIR' named entity 'STUDY' named entity 'MAXIMUM' named entity 'TREATED WITH' named entity 'EFFECT' named entity 'INVOLVED' named entity 'RESIDUAL' named entity 'PARTIAL' named entity 'FASCIOLOSIS' named entity 'MODEL OF' named entity 'MURINE' named entity 'DOSE' named entity 'FASCIOLA HEPATICA' named entity 'ASSESSED' named entity 'MEAN' named entity '2887' named entity 'LIVER' named entity 'DOSE' named entity 'FIZ' named entity 'GROUP' named entity 'DEMONSTRATED' named entity 'PROTEOLYTIC ACTIVITY' named entity 'INHIBITION OF PROTEOLYSIS' named entity 'LIKE' named entity 'TRANS' named entity 'DOSE-RESPONSE RELATIONSHIP' named entity 'USING' named entity 'CARBONYL' named entity 'INHIBITED'

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