About: Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity

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About: Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity
Creator	Gan, Ken-En Su, Chinh, Tran-To Ling, Wei-Li Lua, Wai-Heng Poh, Jun-Jie Yeo, Joshua
source	BioRxiv
abstract	Nickel (Ni) allergy has been reported in contact dermatitis Type IV (Ni-specific T cells mediated) and asthmatic Type I (IgE-mediated) hypersensitivities. Associations between the two hypersensitivities have been found in some patients, but the underlying mechanisms remain enigmatic. Using Her2-specific IgEs as models, we found additional binding to Ni-NTA without observable changes in binding to Her2 and that glutamine, together with the canonical Ni2+-binding histidine, could form Ni2+ binding signatures. This mechanism may underlie Type I hypersensitivity in the selection of anti-Ni2+ IgEs. This mechanism may also underlie Type IV hypersensitivity and the interaction of immunoglobulin proteins with other heavy metal ions. Our findings shed light to how Ni hypersensitivities can occur and how they can be avoided in therapeutics design, or even incorporated for biotechnological purification purposes.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.1101/2020.07.14.203539
has license	biorxiv
sha1sum (hex)	957d927716cdd757a3bf9260a2a61ca08fc4f3ca
schema:url	https://doi.org/10.1101/2020.07.14.203539
resource representing a document's title	Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity
schema:publication	bioRxiv
resource representing a document's body	covid:957d927716cdd757a3bf9260a2a61ca08fc4f3ca#body_text
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